Study Of Expressions Of HIF-1α And E-cadherin In Bladder Transitional Cell Carcinoma And Their Correlation

Diffusion and metastasis of tumors are the primary reason of death of patients who have got cancers. Recent researches have indicated that the dysfunction or down regulation of E-cadherin is related closely to the poorly differentiated, invasion and metastasis of tumor. Hypoxia is common in all solid tumors. The hypoxia-inducible factor-1α(HIF-1α) is the most important factor involved in the cellular response to hypoxia, a local tissue decrease in the oxygen concentration. Nowadays people have commenced to pay close attention to its role in cell adhesion with increasingly interest.To investigate whether expression of HIF-1αis relevant with down regulation of expression of E-cadherin or not, and their effects on biological behavior of bladder transitional cell carcinoma, we examined expressions of E-cadherin and HIF-1αin bladder transitional cell carcinoma by immunohistochemical assay.The results are as the followings:①There is a significant correlation between the expression of HIF-1αwith disease progress, pathological grades and clinic grades in bladder transitional cell carcinoma (p<0.05,p<0.05,p<0.05 respectively);②There is also a significant correlation between the expression of E-cadherin with disease progress, pathological grades and clinic grades in bladder transitional cell carcinoma (p<0.01,p<0.05,p<0.01 respectively);③It's negative correlation between the expression of E-cadherin and HIF-1αin bladder transitional cell carcinoma(p<0.01).Therefore, we think that overexpression of HIF-1αis related to down-regulation of E-cadherin in bladder transitional cell carcinoma, and that Co-detection of HIF-1αand E-cadherin may help estimate the malignency of bladder transitional cell carcinoma. Our results suggest that HIF-1α-E-cadherin may be possible candidates for molecular targeting in the future treatment of bladder transitional cell carcinoma.