The Expression Of The Tyrosine Kinase B In Transitional Cell Carcinoma Of Bladder Tissues And Its Clinical Significance

Bladder cancer is one of the common urinary malignant tumors, which is accounting for 3% of all cancer cases and 6.6% of men malignant tumors. The incidence rate of bladder cancer is the highest one of all urinary malignant tumors, and its recurrence rate is 55~85%. More than 90% of the bladder cancers are transitional cell carcinomas of bladder (TCCB), so the research of the diagnosis, therapy and prognosis of TCCB has great significance. The Tyrosine kinase B (TrkB), the ligand of Nerve growth factor (NGF), plays a critical role in regulating growth, differentiation and apoptosis of cells. Recently, it has been found that TrkB is overexpressed in a number of malignant human cancer types, and can make tumor cells more proliferative, invasive and metastatic. This research shows that the expressions of TrkB of TCCB in the poorly differentiated and invasive TCCB are significantly higher than the rate of the well differentiated and superficial TCCB. TrkB may play an essential role in TCCB and serve as a biomarker for the prognosis of TCCB.Objective To study the expression of tyrosine kinase B (TrkB) and to investigate its relationship with clinical,pathological implications and the parameters of prognosis in transitional cell carcinoma of bladder ( TCCB). Methods Formalin-fixed, paraffin-embedd tissue sections from 60 cases of TCCB and 16 cases of normal bladder were analyzed retrospectively with immunohistochemistry ( S-P method). The results were analyzed with the tumor stage , grade and clinical parameters of prognosis. The patients were followed up for 6-36 months to evaluate the prognosis and the survival time after operation. Results Among the 60 sample cases of TCCB,the expressions of TCCB-positive rate of TrkB were higher than the cell of normal bladder mucous membrane ( P < 0.05) . The results showed that the expressions of TCCB-positive rate of TrkB in the poorly differentiated and invasive TCCB were significantly higher than the rate of the well differentiated and superficial TCCB. The expressions of TCCB-positive rate of TrkB in the recurred cases were much higher than the expressions of the primary cases ( P < 0.05) . Conclusion TrkB may play an essential role in TCCB and serve as a biomarker for the prognosis of TCCB.