The Significance Of The Expression Of HIF-1α And P53 In Patients With Bladder Transitional Cell Carcinoma

OBJECTIVE The purpose is to investigate the expression ofhypoxia-inducible factor 1 alpha (HIF-1α) and p53 in bladder transitionalcell carcinoma (BTCC), and understand the mechanism of invasion andmetastasis of BTCC, and determine its relationship with both clinicalstages and pathological grades.METHODS The expression of HIF-1αand p53 in 45 patientswith baldder transitional cell carcinoma (BTCC) and 7 specimens ofnormal bladder tissue was analysed by immunohistochemical method(Streptavidin/Peroxidase). Compare the expressions of HIF-1αand p53 indifferent grades and pathological stages of BTCC.RESULTS1. HIF-1αand p53 were both positive expression in patients withbladder transitional cell carcinoma(BTCC), the rate of the positiveexpression were 46.7 % (21/45) and 51.1% (23/45), but negativeexpression in specimens of normal bladder tissue (p＜0.025)2. Higher levels of positive expression of HIF-1αwere associatedwith BTCC of higher pathological stage(p＜0.025)3. The level of positive expression of p53 were not associated withBTCC pathological stage (p＞0.05)4. The positive expression of HIF-1αwere associated with BTCC of higher clinical grade (p＜0.05)5. The positive expression of p53 were not associated with BTCCof higher clinical grade (p＞0.05)6. The positive expression of HIF-1αbetween the primary tumorsand the recurrences were not significantly different (p＞0.05).7. The positive expression of p53 between the primary tumors andthe recurrences were significantly different (p＜0.05)8. Significant correlations were found among the expression ofHIF-1αand p53 in patients with BTCC (Rs=0.463,p＜0.05)CONCLUSIONS1. HIF-1αand p53 were both positive expression in patients withbladder transitional cell carcinoma (BTCC), might be connected to thedevelopment of BTCC.2. The positive expression of HIF-1αwere associated with differentclinical grades and pathological stages of BTCC,but significantcorrelations were not found between the primary tumors and therecurrences of BTCC.3. The positive expression of p53 were not associated with differentclinical grades and pathological stages of BTCC, but significantcorrelations were found between the primary tumors and the recurrencesof BTCC.4. Significant correlations were found among the expression of HIF-1αand p53 in patients with BTCC, they both were associated withthe mechanism of invasion, metastasis, and prognosis of BTCC.