| Obesity and hyperlipidemia are major diseases that threat the health of people severely all over the world.At present,the major approaches that treat them have reducing food,taking medicine and surgery,but the effects are not accord with intention.These correlative diseases had started while obesity is being building.The probability of forming high blood pressure, hyperlipidemia and T2 diabetes mellitus is increasing in the obesity-enfant, sometimes,we can discover pathology change of eariy-atherosclerosis in the obesity-enfant.From third class prevent viewpoint,once the obesity had being diagnose,the therapy is not in time.Preventing obesity is being hot topic for medicine and nutrition.The aim of this study is supply new method for the prevention of obesity and hyperlipidemia by investigating the anti-obesity and antihyperlipidemia activity of Kefir,furthermore,we will discuss the possibly existed function mechanisms of anti-obesity and anti- hyperlipidemia of Kefir.1.Taking food weight,body length,body weight and Lee's indexThese mice had being divided into five groups,including natural control group(NC),model control group(MC),low dose group(LD,5g·kg-1), midding dose group(MD,10g·kg-1),high dose group(HD,20g·kg-1).In course of experiment,the taking food weight of everyday of different dose group mice had being noted.Before experiment,after experiment and course of experiment,the body length and the body weight of different dose group mice had being noted.Lee's index had being accounted.As result,①the taking food weight of five different dose groups were not significant difference.②the body length of five different dose groups of male mice were not significant difference,the body length of five different dose groups of female mice were not significant difference.③For male,the body weight increasing of MD group was significant lower then MC group(p＜0.05),whey LD and HD groups were extremely significant lower then MC group(p＜0.01).For female,the body weight increasing of LD group was extremely significant lower then MC group(p＜0.01),MD and HD groups were significant lower then MC group(p＜0.05).④Lee's index of LD,MD and HD were extremely significant lower then MC group(p＜0.01)except LD group of female mice in later.These results exhibited:Kefir can't influence diet and the body length of mice.Kefir debase the body weight increasing and Lee's index of mice.2.Fat index around spermary and ovaryFinishing experiment,these mice were killed.We peel off fat around spermary and ovary and metage it.As result,for male,the fat index of LD group was significant lower then MC group(p＜0.05),MD and HD groups were extremely significant lower then MC group(p＜0.01).For female,MD and HD groups were extremely significant lower then MC group(p＜0.01). These results exhibited:Kefir reduce increase of fat around spermary and ovary of mice.3.Fat index of muscle and liverFinishing experiment,these mice were killed.We sampling a little of muscle and liver tissue from same part of thighbone and liver,and then, metage them.As result of fat index of muscle and liver:①fat index of muscle of HD group was extremely significant difference(p＜0.01).②fat index of liver of MD and HD groups were significant difference(p＜0.05). These results suggest that Kefir reduce increase of inside fat and outside fat, at the same time,suggest that Kefir is excellent on reducing increase of inside fat.4.TC,TG,HLD-c,LDL-c from blood serumCollecting blood from eve and isolating blood serum,we measure the consistence of TC,TG,HLD-c,LDL-c from blood serum.As result:the consistence of TG was not difference.For male,compared with MC group, the consistence of TC of MD and HD groups descended,the consistence of HLD-c of HD group ascended,the consistence of LDL-c of LD and MD groups descended.For female,compared with MC group,the consistence of TC of HD group descended extremely,the consistence of HLD-c of MD and HD group ascended,the consistence of LDL-c of LD and MD groups descended.These result show that Kefir turned down the consistence of TC and LDL-c from blood serum,improved the consistence of HDL-c from blood serum.5.Atherosclerosis indexAs result of account:the atherosclerosis index of MD and HD groups were significant lower than MC group for male mice,the atherosclerosis index of LD,MD and HD groups were significant lower than MC group. These result show that Kefir can keep off happening atherosclerosis.6.FFA from blood serumAs result:the consistence of FFA of HD group was significant higher than MC group.The result suggest that Kefir accelerated to fat metabolism. Conclusion:We consider that Kefir has the function that it can lessen body weight growth and play down Lee's index,at the same time it can adjust body fat distributing and can't influence appetite,Kefir can effectively reduce TC,LDL-c level and enhance HDL-c level from blood serum;it can minish AI and keep off happening atherosclerosis.
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