Research On Relativities Of Perinatal Consequence And Changes Of Plasma Protein In Severe Pre-eclampsia

Hypertensive disease of pregnancy is the most common obstetric high pathological diseases because of unknown etiology and pathogenesis, resulting in lack of control. In addition to pregnant women can cause multiple organ damage, and its recent long-term serious complications prompted perinatal infant mortality high, a poor prognosis.Expect any better perinatal infant prognosis, with the exception of reference to gestational age, gestational age, birth weight and fetal absolutely obstetricians can be based on the important parameters. And among the impacts of pregnancy-induced hypertension diseases and maternal adverse pregnancy outcomes, the greatest one distress obstetricians is forced to terminate the pregnancy, a high rate of prematurity and intrauterine growth retardation, low birth weight and viability of the attendant serious heart inadequate. Intrauterine fetal growth and development in the fetus itself ruled out genetic defects factors, the mother and the placenta and umbilical cord, such as functional status affect fetal growth is an important environmental factors, and meet any embryos and fetal growth and development of many factors, the first of which is still to content the three basic metabolic needs. Three nutrients from the mother through the placenta to transfer matrix approach: free fatty acids is by simple diffusion transfer, the proliferation of glucose easy way to transfer, and only amino acid uses the active transport way in supplying fetus.As we all know, in many pregnant mothers'adaptable or stressful changes, people only observed blood glucose, blood lipids increase, no corresponding increase in the plasma protein. Then the plasma protein changes during pregnancy and hypertensive disorders of pregnancy and fetal outcome has intrinsic link, that is the focus point we start this research for.Methods: January 2007 - 2007 December-patient obstetric hospital in hypertensive disorders of pregnancy severe preeclampsia 50 cases of maternal and fetal (infant) son for the patient group, the average maternal age (31.76±6.3 years). At the same time select 50 cases of normal pregnant women and their children (infants) infants, as the control group, the average age (29.52±4.0 years). In the two groups have been excluded patients with chronic liver and kidney disease. Pregnant women hospitalized after day or fasting blood taken from the business and realized the determination of plasma total protein, albumin, plasma globulin. Recording cesarean section termination of pregnancy gestational age, birth weight and Apgar score. The Diagnostic Criteria is by eight-year–program in the first edition: serum albumin <30 g / L, respectively. This standard will be severe pre-eclampsia patients were divided into group A and group B, group A hypoproteinemia Group 20, Group B non-hypoproteinemia group of 30 patients. Application of SPSS 14.0 statistical analysis software for data analysis, data (x±s) by t test or t 'test, ratio using the chi-square test.Severe preeclampsia group of termination of pregnancy gestational age infants weight both processing through the linear correlation analysis. At the same time the full-term pregnancy of severe pre-eclampsia patients with a total of 15 cases of plasma albumin concentration and birth weight linear correlation analysis.Results: severe preeclampsia plasma total protein (TP), albumin (Alb) concentrations were lower than pregnancy group, the difference between the two groups was significant, P <0.01. Severe preeclampsia group and the normal pregnancy termination of pregnancy gestational age group there was a significant statistical difference, P <0.01. Birth weight also marked significant difference, P <0.01. Case Group of pregnancy termination of pregnancy is less than the control group of normal pregnancy, birth weight was significantly higher. Severe preeclampsia group of termination of pregnancy between gestational age and birth weight linear regression, linear regression equation standardized coefficient R = 0.723, P = 0.000. With the termination of early pregnancy gestational age, birth weight showed decreasing. Full-term pregnancy severe preeclampsia group plasma albumin concentration and birth weight linear correlation exists between, R = 0.926, P = 0.000. That is, in the full-term pregnancy, maternal plasma albumin concentration, the lower the lower the birth weight. Severe preeclampsia hypoproteinemia (group A) and non-hypoproteinemia group (group B) termination of pregnancy gestational age group had no significant statistical difference, P> 0.05. But birth weight difference was significant, P <0.01. Hypoproteinemia group than non-hypoproteinemia low birth weight. In gestational age there was no significant difference, hypoproteinemia group of stillbirths and neonatal mortality than non-hypoproteinemia group, the difference was significant, X2 = 8.0592, P = 0.0045. Neonatal Apgar score significant difference between the two groups, X2 = 8.4028, P = 0.015. Hypoproteinemia newborns Apgar score was significantly lower than that of non-hypoproteinemia group.Conclusion: severe preeclampsia and perinatal infant outcome of termination of pregnancy gestational age, serum albumin concentration, and plasma albumin is closely related to the changes of time. Severe pregnancy-induced hypertension disease preeclampsia plasma protein changes can be used for monitoring changes and disease forecast perinatal infant outcome indicators. Plasma protein concentration decreased the greater the change sooner, perinatal infant smaller weight, the poorer the prognosis. Maintain maternal plasma albumin level is conducive to improving maternal preeclampsia severe circulatory disturbance state, improve perinatal infant outcome.