The Prethrombotic State Of Complex Diseases On Abnormal Savda Syndrome

Objective:To understand the distribution of Abnormal Savda syndrome in complex diseases.Observe the pre-thrombosis markers in patients of different body fluids and to explore the matiarialistic basis of Abnormal Savda syndrome.Methods:The expression of CD41,CD62p on platelets,the level of plasma tissue plasminogen activator(t-PA) and its inhibiter(PAI-1),the level of endothelin(ET-1),Activated partial thromboplastin time(APTT),Fibrinogen(FIB),Prothrombin time(PT) and Thrombin time(TT) were tested by using Flow Cytometer,ELASA method,radioimmunoassay method and auto coagulometer.Results:(1)There were 188 cases of Abnormal Savda patients and 97 cases of non Abnormal Savda patients among 285 cases of complex disease patients:among the total clinical cases,the ratio of Abnormal Savda patients was 65.95%,the ratio of non Abnormal Savda patients was 34.04%,the ratio of Abnormal Savda patients is much bigger than the ratio of non Abnormal Savda patients.(2) Compared to control group,the average expression of CD62P,the level of plasma PAI-1,FIB and the level of serum ET-1 in Abnormal Savda group were significantly increased(P＜0.05):the level of t-PA in Abnormal Savda group was decreased:there was no difference on the expression of CD41 between Abnormal Savda group and the control group(P＞0.05):compared to control group,the APTT and PT were significantly shortened in Abnormal Savda group (P＜0.05):there was no significant changes in TT between two groups(P＞0.05)。(3) Compared to control group,the level of ET-1 were significantly increased in both Abnormal Savda and non Abnormal Savda groups(P＜0.05):Compared to Abnormal Kan and Abnormal Sapra groups,the level of ET-1 was higher in Abnormal Savda group(P＜0.05):the level of ET-1 had Gradient variations among four fluid groups and the control group:Abnormal Savda＞Abnormal Sapra＞Abnormal Kan＞Abnormal Balham＞control group.Compared to control group,there was no significant change on the expression of platelet CD41 in Abnormal Savda and non Abnormal Savda groups (P＞0.05):the expression of CD62P was significantly increased(P＜0.05),Compared to Abnormal Kan and Abnormal Balham groups,the level of CD62P was higher in Abnormal Savda group(P＜0.05),the level of CD62P had Gradient variations among four fluid groups and the control group:Abnormal Savda＞Abnormal Sapra＞Abnormal Kan＞Abnormal Balham＞control group.Compared to control group,the level of plasma t-PA significantly lowered in Abnormal Savda and non Abnormal Savda groups(P＜0.05):the level of plasma PAI-1 was increased significantly(P＜0.05):the level of t-PA had Gradient variations among four fluid groups and the control group:Abnormal Savda＜Abnormal Balham＜Abnormal Sapra＜Abnormal Kan＜control group:the level of PAI-1 has Gradient variations among four fluid groups and the control group:Abnormal Savda＞Abnormal Balham＞Abnormal Sapra＞Abnormal Kan＞control group.Compared to control group,the level of plasma FIB was significantly higher in Abnormal Savda and non Abnormal Savda groups(P＜0.05),PT,APTT was significantly shortened(P＜0.05), but there was no difference in TT(P＞0.05).Compared to Abnormal Kan and Abnormal Sapra,the level of FIB was significantly increased(P＜0.05):the gradient change of FIB was Abnormal Savda＞Abnormal Balham＞Abnormal Sapra＞Abnormal Kan＞Control:the gradient change of PT and APTT was:Abnormal Savda＜Abnormal Balham＜Abnormal Kan＜Abnormal Sapra＜Control:TT had no gradient change among these groups.Conclusion:1.Abnormal Savda Syndrome is the major type of complex diseases.2.There is prethromboitic state both in abnormal Savda and non abnormal Savda syndromes of complex diseases,which can be observed in the injury of vessel epithelial cells,increased platelet activity,increased blood viscosity, decreased fibronolytic function.The prethromboitic statein on Abnormal Savda syndrome is more obvious than the non abnormal savda syndrome,from above results, we can see that when there is complex disease,there exists potent Abnormal Savda syndrome.3.As for complex diseases,no matter how significant the Abnormal Savda syndrome characteristic,we have to consider the application of Abnormal Savda Munsiq and Mushil in order to prevent the further development of complex diseases.