Evaluation Of MR Diffusion Weighted Imaging In Liver Cirrhosis

Hepatic cirrhosis is very common in clinic, which is the major reason of liver malignant tumors. Earlier period hepatic cirrhosis always has no specific clinical symptom while imaging examination can precise reflect earlier period status. With the development of magnetic resonance technology, diffusion weighted imaging can reflect interior physiological status and pathological status by detecting the water molecular motion state which can provide valuable reference index for clinic .The text main discuss the ADC value of different degree hepatic cirrhosis, through the application of diffusion weighted imaging in liver cirrhosis.Objective: To investigate the correlation between the change of apparent diffusion coefficient (ADC) value of magnetic resonance diffusion weighted imaging (DWI) and severity of cirrhotic liver.Methods: 48 normal liver patients were confirmed by those through clinic and imaging examination without liver and spleen pathological changes and laboratory examination without abnormity. 54 patients with liver cirrhosis through clinic,medical and laboratory examination were testified. Those hepatocirrhosis sufferer were classified into 23 cases Child A, 18 cases Child B, 13 cases Child C. Liver cirrhosis and diffusion weighted imaging were performed in 54 patients with liver cirrhosis and 48 normal liver, and the ADC values of the liver were measured, the b values were 0, 400, 600 and 800 s/mm²in the sequence respectively. DWI can differentiate earlier period cirrhosis from normal liver. When the b values were 600 and 800s/mm²in the sequence, considering 1.30×10^-3s/mm² was the demarcation point, whose value lower than which was hepatic cirrhosis. Although the grades among cirrhosis had distinguished difference, there was no definite value as quantitation standard for classification. In terms of suitable b value, the ADC value can serve as a valuable index for the evaluation of hepatic fibrosis. Through the research, we considered the suitable b value was between 400-600s/mm².Results: the mean ADC₁,ADC₂,ADC₃in cirrhosis were significantly lower than those in normal livers, the ADC value were lower in Child A,Child B and Child C than those in normal livers, the ADC value reduce with the severity of cirrhosis; the ADC values decrease when b value increase responding.Conclusion: Measurement of ADC value is a valuable parameter that can reflect dynamic changes in liver cirrhosis. The ADC values change can assist clinic diagnosis forepart liver cirrhosis and estimate the severity of cirrhosis.