| Objective: To explore the effects of calcium intake on serum cholesterol concentration in hypercholesterolemic human body and provide basic evidence for prevention of cadiovescular disease by lowering serum cholesterol concentration via regulating dietary pattern and nutrient intake reasonably.Methods: A crossover-randomized experimental design was carried out on the hypercholesterolemic women. Ten of them were supplemented with 1000 mg of calcium in calcium carbonate each day for 28 days based on their regular diet. Another ten were as control. Serum lipid concentrations of all objects were measured at the final day of this experimental period. After 21 days for washing-up, the objects in the two groups were crossover and supplemented with calcium for another 28 days. Then their serum lipid concentrations were measured. Dietery Servies of 3 days each were carried out during the two experimental periods mentioned above.Rusults: At the end of the first period of calcium supplementation, profiles of serum lipids from the experimental group were lower than that from control group without significant. Compaired with the control group, serum concentration of total cholesterol and low density lipoprotein cholesterol were lowered by 9.5% (P=0.082) and 8.9% (P=0.096) respectively in the experimental group. Compared with the initial day, except apolipoprotein A, the profile of serum lipids in experimental group was significantly low at the end day of the experimental period (P<0.05). Accordingly, that in control group was not significant. At the end of the second period of calcium supplementation, profile of serum lipids from the experimental group was higher than that from control group without significant. Compared with the initial day,except the concentration of triglycerids and apolipoprotein A , the change of serum lipid profile in experimental group was not significant at the end day of the experimental period. Accordingly, that in control group also was not significant. The results of dietary servies indicated that the edible oil intake of the experimental group were 35g per person per day during second calcium supplementation period. This resulted in the propotion of energy supplied by fat reaching to 36.2% that higher than that of control group (P<0.05). Meanwhile, the carbohydrate and dietary fiber intake of the experimental group were lower than that of control, leading to a lower proportion of energy supplied by carbohydrate compared with that of control group (P<0.05).Conclusion : Supplementation of 1000mg of calcium to hypercholesterolemic object every day is beneficial to improving the serum lipid profile, especially the serum cholesterol level, under this experimental conditions. But the effect is impacted by dietary factors. Neither exceed intake of edible oil, meat and poultry, nor less inke of cereal and dietary fiber is beneficial to reduction of serum cholesterol concentration. |
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