Continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Of Hypoxic-ischemic Encephalopathy Of The Preliminary Study On Full-term Newborns

IntroductionNeonatal hypoxic-ischemic encephalopathy is a fetal and neonatal brain damage caused by various perinatal factors are responsible for hypoxia and cerebral blood flow reduce or suspend , the most common in full-term infants may be secondary from cerebral palsy, mental retardation, growth and development of backward, diseases such as epilepsy an important factor. However neonatal hypoxic-ischemic brain injury and accurately determine the clinical prognosis is difficult. Imaging checks to be directly reflected intracranial lesion type, degree and the evolution process for the early clinical diagnosis and treatment and provide an objective basis for evaluating prognosis. Cerebral blood flow (CBF) Determination to a certain extent, reflect real-time changes in cerebral hemodynamics, and to evaluate neonatal brain injury perfusion one of the important parameters. Hence, early, dynamic monitoring of CBF changes, the study HIE pathogenesis and treatment guidance HIE great significance. Has been through intravenous contrast agent injection or the use of nuclear medicine in pediatrics CBF measured in the remaining technical difficulties and doubts on the Ethics. Arterial spin labeling perfusion MR imaging is a free diffusion of water as endogenous tracer MR perfusion imaging methods, non-invasive cerebral perfusion study might provide. And the traditional contrast injection of contrast agent injection and nuclear medicine test, a noninvasive, quantitative measurement of cerebral blood flow and easy to repeat the advantages of imaging and clinical studies provide more room.PurposeIn this study, continuous arterial spin labeling (CASL) Magnetic resonance perfusion method of neonatal hypoxic-ischemic encephalopathy in patients with quantitative measurement of CBF to study neonatal hypoxic-ischemic encephalopathy early hemodynamic changes of a row Arterial spin labeling (CASL) MR perfusion imaging in neonatal hypoxic-ischemic encephalopathy early diagnostic value.Materials and MethodsOn the full-term newborn hypoxic-ischemic encephalopathy in children with 12 cases and full-term newborns to the normal control group of 12 cases in the post-natal 8-24 hours, 48 hours, 7-12 days respectively conventional T1WI, T2WI, DWI and CASL Perfusion MR examination. Four cases of the control group did not achieve inspection 7-12 days; PHILIPS PRIDE reconstruction package adopted each study the CBF map, Measured in the bilateral parietal cortex, the white matter corona radiata, the basal ganglia in cerebral blood flow (CBF).ResultsIn the normal control group, full-term infants parietal cortex CBF than the low basal ganglia, a statistically significant difference (P <0.01), white matter CBF for the relatively low gray with a significant statistical difference (P <0.01). Experimental group interested District 8-24 hours CBF value compared with the control group was significantly lower level, a statistically significant difference (P <0.05). In the 48 hours after hypoxia-ischemia, the experimental group of white matter CBF with the control group there was no significant difference (P> 0.05), basal ganglia and parietal cortex CBF increased significantly (P <0.05). 7-12 days normal group and the control group interested CBF district there was no significant difference (P> 0.05).ConclutionContinuous arterial spin labeling (CASL) perfusion magnetic resonance imaging technology can be used in full-term neonates with hypoxic-ischemic encephalopathy early diagnosis of disease and the development of dynamic observation. In the normal newborn gray matter than white matter CBF low. HIE full-term newborn children with changes in gray matter CBF low - high - low trend for the performance of white matter after the hypoxic-ischemic CBF to reduce short-term.