| Application of magnetic resonance arterial spin labeling in term neonates withasphyxiaObjectives:To investigate the changes of brain perfusion after perinatal asphyxia in term neonates using magnetic resonance arterial spin labeling to guide clinical treatment,improve the prognosis of children,and reduce the occurrence of neonatal brain injury.Methods: A total of 12 full-term neonates with a history of asphyxia were examined by conventional MRI and 3D-ASL examinations using GE 3.0T superconducting magnetic resonance.In addition,15 normal term newborns were collected as control groop.Their cerebral perfusion images are obtained.Using ADW4.6 workstation functool software to obtain false color images for image processing,and the false color images and T2 WI images were merged.Cerebral blood flow was measured in bilateral frontal lobes,basal ganglia and thalamic regions on fusion images,the differences between the full term newborns with asphyxia and the normal term children were analyzed.Result: Asphyxiated newborns were examined at the age of 7.833±3.927 d,gestational age at 39.050±1.138 w,and body weight at 3.255±0.393 kg.The age of control group was 9.333±3.457 d and gestational age was 38.420±0.766 w and body weight was3.238±0.343 kg.There were not statistically different.The CBF of bilateral frontal lobe,basal ganglia and thalamus in neonates with asphyxia were 8.658±1.781ml/100g·min,16.039±4.039ml/100g·min,and 17.673±5.320ml/100g·min;the control group was 8.311±1.017ml/100g·min,13.324±2.644ml/100g·min,and 14.209±3.241ml/100g·min.In the basal ganglia and thalamus,the asphyxiation group had higher CBF than the term infants(P<0.05).There was no significant difference in the CBF between the frontal white matterregion(P>0.05).In the asphyxiation group,there were 7 cases with mild asphyxia(Apgar score 4-7 points)and 5 cases with severe asphyxia(Apgar score ?3 points).The CBF in the white matter area of the frontal lobe of severe asphyxia(7.672± 1.441ml/100g·min)was lower than that of neonates with mild asphyxia(10.037±1.240ml/100g·min),the difference was statistically significant(P<0.05).There was no significant difference between the two groups in basal ganglia and thalamus.Conclusion: The CBF in the basal ganglia and thalamic regions of neonates with term asphyxia increased compared with those in the normal term newborns,but there was no significant difference in the CBF in the frontal white matter area.The CBF in the frontal white matter area of children with severe asphyxia was lower than that in children with mild asphyxia.3D-ASL can help early detection of high perfusion in the brain of the term asphyxiated neonates,so as to achieve the purpose of preventing brain injury.It is of research value to evaluate the brain perfusion of term newborn infants with asphyxia.Application of magnetic resonance arterial spin labeling in cerebral perfusion in preterm infantsObjectives: To analyze the differences in cerebral blood flow between different corrected gestational age preterm infants and normal term infants with term 3D-ASL,and to explore the correlation between cerebral blood flow and corrected gestational age,and to investigate changes in cerebral perfusion in preterm infants.To assess the relationship between cerebral perfusion and neonatal brain maturation.Methods: Conventional MRI and 3D-ASL examinations of 26 cases of preterm infants and 13 normal term infants were performed using GE 3.0T superconducting magnetic resonance.Their brain perfusion images were obtained using the ADW4.6 workstation functool software.A pseudo-color image was obtained for image processing,and the false color image was merged with the T2 WI image.The CBF values of the bilateral frontal white matter,basal ganglia,and thalamus were measured on the fused image,and the cerebral blood was analyzed between different parts of the preterm and full-term children.Differences in flow and correlation between cerebral blood flow and corrected gestational age.Result: Among 39 subjects,preterm infants corrected gestational age <37 weeks had 11,15 corrected gestational age?37 weeks,13 normal normal infants,The CBF of the preterm infants corrected gestational age <37 weeks and normal term infants was less than the preterm infants corrected gestational age ?37 week,the difference was statistically significant(P<0.05).There was no significant difference between the preterm infants corrected gestational age <37 week and normal term infants(P>0.05).In each corrected gestational age period,the basal ganglia and thalamus had statistically significant differences in CBF and frontal white matter(P<0.05).The basal ganglia and thalamus were larger than the frontal white matter,and between basal ganglia and thalamus,difference was not statistically significant(P>0.05).Conclusion: In preterm infants,the CBF of the preterm infants corrected gestational age was reduced compared with corrected gestational age of ? 37 weeks,whereas preterm infants with corrected gestational age ? 37 weeks had higher CBF than term infants of the same age.There are certain differences in CBF values in different parts of the brain tissue.CBF is significantly higher in the thalamus and basal ganglia of preterm infants and full-term infants than in the frontal white matter,but the CBF value is no significant difference between the thalamus and basal ganglia.Therefore,3D-ASL has important research value in evaluating cerebral perfusion in preterm infants. |
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