Clinical Analysis Of Juvenile Recurrent Respiratory Papillomatosis Associated With Human Papilloma Viral Types 6 And 11 In A Large Pediatric Population In XINJIANG

Objective to investigate the Human papilloma viral types 6 and 11 in a large pediatric population in XinJiang and its relationship with pathological characteristics of juvenile Recurrent Respiratory Papillomatosis(JRRP).Methods Using polymerase chain reaction(PCR),we analyzed paraffin embedded tissue in 42 cases of juvenile Recurrent Respiratory Papillomatosi(sJRRP)and determined the HPV types 6 and 11, and to correlate these results with retrospectively analysis about those cases who were consecutively treated in our ENT department, meanwhile we carry out a critical review of the literature of JRRP. Results A total HPV infection positive rate was 97.61%(41/42), and HPV11 positive rate was 63.41%(41/26) ,HPV6 positive rate was36.58%(41/15). HPV6+HPV11 positive rate was 17.07%(7/41). In minority people HPV11 positive rate was 40.48%(17/41),HPV6 positive rate was19.05%(8/41),HPV6+HPV11 positive rate was11.90%(5/26). in Chince people HPV11 positive rate was 21.43%(9/41),HPV6 positive rate was16.67%(7/41),HPV6+HPV11 positive rate was4.76%(2/41) ,The post- operation relapse rate in HPV11-positive group was42.30% ,and in HPV6-positive group was 20.0%. Conclusion Juvenile laryngeal papilloma is associated with HPV11 , HPV6 infection and we considered that HPV11 infection may be the important guideline of the evaluation of disease prognosis.but no statistical signtificance was determined in the patients of various ethnic groups in Xin jiang ( P > 0. 05).