Regulation Of Sex Hormone In Obstructive Sleep Apnea/hyponea Syndrome Patients

Objective To explore the regulation of sex hormone level in men with obstructive sleep apnea/ hyponea syndrome (OSAHS).Method OSAHS patients (OSAHS group) and subjects with simple obesity alone (control group) were monitored by polysomnography (PSG) .The two groups were age and BMI matched .The serum luteinizing hormone (LH) ,follicular-stimulating hormone (FSH) and testosterone (T) level were measured by radioimmunoassay before or after sleep .Their correlation were analyzed .Results The serum LH, T concentration〔(3.7±1.5) mIu/ml,(4.5±1.5) ng/ml〕in OSAHS group were significantly decreased than those of the control group〔(12.4±2.1)mIu/ml,(6.3±1.5)ng/ml〕(P﹤0.01) ; FSH level decreased in OSAHS group (4.1±0.9 mIu/ml)compared with the control group(11.5±1.9mIu/ml).After adjusting for age and body mass index (BMI),the bivariate correlation analysis of the OSAHS group indicated that serum LH level was negatively correlated with apnea hypopnea index (AHI)(r=-0.1461,P﹤0.01),bascial oxygen saturation(BSaO2)(r=-0.5548,P﹤0.01)and the lest level oxygen saturation(LSaO2)(r=-0.5431,P﹤0.01);serum testosterone (T) level was negatively correlated with apnea hypopnea index (AHI) ( r = -0.7767 , P﹤0.01),bascial oxygen saturation(BSaO2()r=-0.5758,P﹤0.01)and the lest level oxygen saturation(LSaO2()r=-0.5644,P﹤0.01); serum follicular-stimulating hormone (FSH) did not have significant correlation with apnea hypopnea index (AHI),bascial oxygen saturation(BSaO2) and the lest level oxygen saturation(LSaO2).Conclutions OSAHS in men is associated with dysfunction of pituitary-gonadal axis ,and the feedback regulation is disordered These abnormalities are related to the severity of sleep apnea and hypoxia during sleep.