Clinical Study Of Gastromyoelectric Activity Changes In Patients With Gastroesophageal Reflux Disease

Objective:Our aim was to investigate the behavior of gastromyoelectric in patients with gastroesophaeal reflux disease (GERD),and the effect of gastric dysmotility in pathogenesis of GERD.Methods:68 patients with GERD were randomly chosen in this study.30 healthy Volunteers were used as normal control.All the patients and volunteers underwent fasting and postprandial electrogastrogram(EGG) examination.Patients with GERD were divided into 2 groups according to the result of gastroscopy:reflux esophagitis(RE)group and non-erosive reflux disease(NERD)group.The prevalence of gastric dysrhythmias were compared between the two groups,we also divided GERD group into 2 groups according to the result of symptom scores:the low symptom scores group and the higher symptom scores group.we also analyzed them with the prevalence of gastric dysrhythmias.19 patients with gastric dysrhythmia underwent the second EGG examination after one week's treatment.The EGG parameters were analyzed before and after the treatment.Result:Compared with control group,dominant Frequency(DF),DF in normal range(N%)and posprandial to fasting power ratio(PR)were obviously decreased,especially after test meal(p＜0.05 or 0.01).Gastric electrical rhythm in GERD was disordered,and mainly displayed as bradyastria.The clinical symptoms were alleviated or disappeared in our clinical trial.At the same time,the EGG parameters of 19 patients with gastric dysrhythmia were improved significantly after the therapy(p＜0.05 or 0.01).The prevalence of preprandial gastric dysrhythmia in RE group was higher than that in GERD group(39.3%vs14.3%,p＜0.05).The prevalence of postprandial gastric dysrthythimia were 69.7%in RE group and 60%in NERD group.But,there was no statistical difference(p＞0.05).Conclusion:There were abnormal preprandial and postprandial gastric electrical activities in patients with GERD.Gastric dysmotility may play an important role in the Pathogenesis of GERD.Electrogastrogram can provide guide for diagnosis and therapy for GERD.