The Simulation System Of Microcirculation Metabolic Regulation And Its Application

Circulation system is composed of the heart and blood vessels of all levels to deliver blood to the whole body, and its peripheral microvessels are the only places where the metabolic substances are exchanged, provide nutrients, oxygen for organs in the body and exclude metabolites such as CO2 . Metabolic regulation is the main way in the regulation of microcirculation, one of the main regulators of the circulatory system, performing more than 75% of the regulation function. Although much work on microcirculation metabolic regulation has been done in the past, its precise mechanism has not been illustrated so far. At the same time, due to the limit of current in vivo experimental ways, illustrating the mechanisms still has a lot of difficulties. Thereby, the aim of this study is to establish the micro-model of the circulatory system through computer programming on the basis of new theoretical model on metabolic regulation in microcirculation, and thus building its discrete theoretical model. Furthermore, metabolic adjustment mechanism of microcirculation and its application by computer simulation have been studied. This paper mainly contains the following four parts.Firstly, research background and basic understanding of relevant subjects. This part introduces the basic components and functions of the microcirculation, describes the mode of operation of microcirculation regulatory mechanism in detail, and focuses on the metabolic regulation of the mode. From a view of biochemistry, the metabolic adjustment mechanism from previous data has been introduced, substances and factors that regulate the micro-cycle have been discussed. Several controversial issues existing between the theory and practice have been raised.Secondly, on the basis of the new theoretical model of microcirculation metabolic regulation, we focus on the special regions where capillaries distribute uniformly. When the metabolic status changed abruptly during a short period of time due to in vitro or in vivo impact of environmental conditions, the discrete expression of the metabolic regulation in the capillaries and the model among three parameters such as state of open-close, open capillaries rate, and the opening frequency have been established. This provides simulation analysis of the circulatory system with solid basis. What's more, impact factors of open capillaries rate and the opening frequency have been analyzed and discussed.Thirdly, on the contrary, when the metabolic state changes gradually within longer period of time due to in vitro or in vivo changes of environmental conditions, the expression of discrete state for the metabolic regulation of capillaries and the model between microcirculation metabolism and capillary system state were established. Establishing experimental simulation platform for metabolic regulation theory of microcirculation provides basis for not only clinical cases but also computer analysis software. With comparison and analysis of the experiment results of metabolic regulation of microcirculation, the utility of which has been discussed.Lastly, using this model, the open-close state of capillaries, the opening rate as well as switching frequency have been discussed and analyzed under various conditions. The mechanism that the capillaries try to meet the oxygen requirement of the body, and at the same time maintain the dynamic equilibrium of the blood pressure and blood flow at all metabolic levels are illustrated.And we tried to explain common physical and clinical pathological phenomena with this theory.A preliminary progress on the computer simulation platform of the metabolic regulation of microcirculation has been obtained. In addition this job affords an approximative simulation method and initial software for further study.