Association Between PAI-2 Gene Polymorphism And Coronary Heart Disease

AIM:To study the allele frequencies and genotype distribution of the PAI-2 gene in Chinese patients with coronary heart disease(CHD),and to analyze the association between the PAI-2 gene polymorphism and CHD.METHODS:The polymorphism of the PAI-2 gene was analyzed by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 57 patients with CHD and familial history and 62 controls without CHD or familial history to research the influence of the gene polymorphism on CHD.RESULTS:The distribution of the PAI-2 gene Ser/Cys⁴¹³15588 G/C polymorphism was significantly different between the CHD group and the control group(P＜0.05).The allele frequencies distribution between the 2 groups is also very different(P＜0.05).The relative risks of different genotypes for CHD are:CC is a risk factor for CHD(OR =2.405,95%CI:1.059～5.667);GG is a protective factor for CHD(OR=0.303,95%CI:0.089～1.029).the relative risk in C allele carriers was 28.881 times as high as that in G allele carriers(OR =28.881,95%CI:1.96～437.618).CONCLUSION:The PAI-2 gene Ser/Cys⁴¹³15588 G/C polymorphism is associated with CHD;the C allele is a risk factor for CHD and the G allele is a protective factor for CHD.