Expression Of ERCC1,RRM1 In Non-Small Cell Lung Cancer And Prognostic Benefit From Cisplatin Plus Gemcitabine Chemotherapy After Surgical Resection

Objective:To investigate the relationship between the expression level of ERCC1,RRM1(members of nucleotides excision repair system)in resected stageâ…¡-â…£patients with Non-small cell lung cancer(NSCLC) and the benefits from postoperative cisplatin plus gemcitabine chemotherapyMaterials and methods:1.Among all stageâ…¡-â…£patients with NSCLC who are consistent with inclusion criteria from 2000 to 2006,68 patients were selected randomly and followed up after clinic datum were reviewed. Eventually,57 patients were taked in our study.2.The expression of ERCC1,RRM1 were determined by immunohistochemistry in the paraffin-embedded tumor specimens of the 57 samples.3.Proportions were compared by use of Chi-square test,Survival curves were produced and median survival times were estimated using the method of Kaplan -Meier.Comparisons of the survival curves of groups were based on the log-rank test.Cox proportional hazards regression was used for Multivariate analysis.Results:1.Among the patients with high expression of ERCC1,the survival time in chemotherapy group are longer significantly than in non-chemotherapy group(P=0.018),yet no significant difference among the ones with low expression of ERCC1(P=0.088)2.Among the patients with low expression of RRM1,the survival time in chemotherapy group are longer significantly than in non-chemotherapy group(P=0.010),but no significant difference among the ones with high expression of RRM1(P=0.092)3.Multivariant analyses showed the expression level of ERCC1,chemotherapy after surgical resection,completely and incompletely surgical resection were independent prognostic factorsConclusions:1.The resected NSCLC patients with high expression of ERCC1 can benefit from postoperative cisplatin plus gemcitabine chemotherapy. however,the ones with low expression cann't.2.The resected NSCLC patients with low expression of RRM1 can benefit from postoperative cisplatin plus gemcitabine chemotherapy. however,the ones with high expression cann't.3.the expression level of ERCC1,chemotherapy after surgical resection,completely and incompletely surgical resection were independent prognostic factors...