| Objective: To evaluate the clinical applied value of activated carbon particles with mitomycin to guide gastric cancer lymphadenectomy.Methods: Fifty three patients who was in hospital to receive therapy at general surgery in QiLu hospital during January 2007 to January 2008 were divided into two groups -activated carbon group and control group. 16 cases of gastric cancer received activated carbon particles with mitomycin(MMC-CH40) injection as activated carbon group and the others as control group . In the activated carbon group , MMC-CH40 was injcted into the Subserosa and the lymph nodes around the tumor during the operation , the black-stained lymph nodes were regarded as marker of the operation. The patients of control group were received radical surgery of gastric cancer. The number of dissected lymph nodes, black-stained lymph node, positive lymph node and the side effect of the procedure were analyzed respectively.Results: (1) The average lymph nodes resected was higher in activated carbon group (32. 7±11. 4) than in control group (17. 0±8. 7) ( P < 0. 05), especially in N2 (23. 1±8. 0)than in N1 (8. 7±4. 2). (2) The total black-stained ratio of lymph node was 58. 2%, with Nl (66. 7%) and N2 (49. 8%) in activated carbon group. (3)The positive rate of lymph node was higher in black-stained lymph node of activated carbon group (20.7%) than in unstained lymph node of activated carbon group(3.7%) and control group(15.2%). (4)The operative periods was slighted longer in activated carbon group than in control group, with same operative complications. No serious side effect happened of activated carbon particles injection in local gastric tissue.Conclusions: Local injection of activated carbon particles around the tumor is an efective, easy and safe procedure to guide gastric cancer lymphadenectomy. |
PDF Full Text Request