Rudiment Analysis Of Functional Connectivity Changes In Parkinson's Disease With The Tpye Of Endogenous Liver Wind In Resting State

ObjectiveParkinson' s disease (PD), which belong to "tremble and rigidity disease" in traditional Chinese medicine, is a progressive neurodegenerative disorder characterized by static tremor and bradykinesia. At present, the diagnosis of PD is subjective, which depend on clinical symptom. Therefore, We use fMRI to hunt for the diagnosis of Parkinson' s disease , which is sensitive and specific. To investigate functional connectivity changes in Parkinson' s disease with the tpye of Endogenous liver wind in the resting brian using magnetic resonance imaging.MethodsNine Parkinson' s disease patients and eight healthy volunteers participated in the experiment. The patients are consistent with the diagnostic criteria of PD between December 2007 and April 2008.The control group and the PD group were matched by gender and age .MR data acquired in the resting state were analyzed to investigate functional connectivity changes in PD patients and controls, while bilateral globus pallidus were chosen as seed point. Correlation analysis was carried out between the seed reference and the whole brain in a voxel-wise manner. A Fisher' s z-transform was applied to improve the normality of these correlation coefficients The individual z value was entered into a random effect one-sample t test in a voxel-wise manner to determine brain regions showing significant connectivity to the bilateral globus pallidus within each group. These values were also entered into a random effect two-sample t test. According to AlphaSima ' result, interclass threshold was set at P < 0.05 and a minimum cluster size of 563mm~3 was used to space correct for multiple comparisons. ResultsIn age-matched healthy controls, there are some regions had functional connectivity with bilateral globus pallidus, including bilateral temporal pole, bilateral hippocampus, bilateral thalamus, posterior cingulate cortex, right middle occipital gyrus and right superior parietal gyrus. In PD, regions including bilateral cerebellum, left hippocampus, bilateral superior temporal gyrus, left inferior frontal gyrus, left middle frontal gyrus, left anterior central gyrus, left inferior parietal gyrus and left superior parietal gyrus, had functional connectivity with bilateral globus pallidus. Compared with controls, increased functional connectivity in bilateral cerebellum, bilateral temporal lobe, left frontal lobe and left parietal lobe, decreased functional connectivity in bilateral thalamus were observed in PD. ConclusionFunctional connectivity MRI is a useful tool that can provide new evidence for early diagnosis in Parkinson' s disease.