Expression Of Cancer-Testis Antigen Expression Of MAGE-A1 In Human Retinoblastoma(RB) And Its Significance

Objective:To investigate the expression of Cancer-Testis Antigen MAGE-A1 in human retinoblastoma,and explore the potential possibility in the immunodiagnosis and immunotherapy of retinoblastoma with MAGE-A1.Methods:With immunohistochemistry,the MAGE-A1 was examined in the tumor tissues of 30 retinoblastoma cases and normal retina tissues of 25 normal retina tissue cases.The correlation between the expression of MAGE-A1 and clinical.data was analyzed by statistical method.Result:The expressive frequency of MAGE-A1 was 20%(6/30)in retinoblastoma.There was no MAGE-A1 detected in normal retina tissue cases. Significant relationship was found between them(P＜0.05).No significant relationship was found between the expression of MAGE-A1 and clinical data, such as gender,nation and the size of the tumor(P＞0.05),but it was related with the age(P＜0.05),children younger than 2 years old were more lined to express. Besides,it was related with the clinical stage(P＜0.01).No significant relationship was found between the expression of MAGE-A1 and optic nerve infiltration(P＞0.05).No significant relationship was found between the expression of MAGE-A1 and histological typing(P＞0.05). Conclusion:MAGE-A1 was expressed in retinoblastoma,suggesting that MAGE-A1 might be a target antigen specific for immunodiagnosis and immunotherapy of retinoblastoma cases.