| Objective: By detecting LPA of plasma and CA125 of serum in the patients with ovarian cancer, ovarian benign tumor, chocolate cyst of ovary and the normal healthy woman, the significances of LPA in diagnosis in the patient with ovarian cancer; the diagnosis value of LPA in patient with the early-stage ovarian cancer and the value as the prognosis index for postoperative ovarian cancer are to be appraised.Method: A test group consisted of 28 patients with ovarian cancer; 20 patient with ovarian chocolate cyst; 20 patient with benign ovarian tumor from the First Hospital of Guangxi Medical University during August 2006 to March 2007. And a control group 20 healthy women from medical examination center of Guangxi Medical University. The final diagnoses were confirmed by histopathology for all the patients apart from the healthy women. Biochemistry method was adopted to detect the LPA level in their plasma. Having been picked up, separated and digested, LPA from plasma was displayed by display fluid to measure the absorption of light in 636nm, with its values accounted. The reagents were produced by Beijing Taifushi Company. Serum CA125 was determined by MEIA. Using SPSS 11.0 statistical software for statistical analysis.Result:1. ovarian cancer group plasma LPA was 5.25±1.57umol/L, ovarian benign tumor group blood plasma LPA 1.74±0.71umol/L, the ovarian chocolate cyst group blood plasma LPA 2.99±1.28umol, normal control group blood plasma LPA 1.85±0.35umol. Comparing the plasma LPA level in ovarian cancer group with that of the ovary benign tumor group, the ovarian chocolate cyst group, the normal control group, plasma LPA levels of patients with ovarian cancer is significantly higher than those of benign ovarian tumor, ovarian chocolate cyst and healthy controls (P<0.05) . The sensitivity of LPA in diagnosis of ovarian cancer is 89.29% (25/28), the specificity is 85% (51/60). But the sensitivity of CA125 is 75% (21/28), the specificity is 76.67% (46/60).Comparing the sensitivity and specificity of LPA and CA125 in diagnosing ovarian cancer, the sensitivity of LPA is higher than that of CA125(P<0.05); But the specificity is not statistically significant(P>0.05).2. The preoperative and postoperative plasma LPA levels in ovarian cancer group are obviously different. The plasma LPA level was 5.25±1.57umol/L in preoperative patients with ovarian cancer, the plasma LPA 3.10±1.30 umol/L a week after operation. Comparing the two groups, the difference has statistical significance(P<0.01), the postoperative levels of LPA obviously drops.3. There is no significant relation between LPA value of ovarian cancer histopathologic types and histological grade, but there is correlation in the clinic stages. The LPA level in patients with ovarian serous cystadenocarcinoma was 5.35±1.53umol/L, the LPA level in patients with ovarian mucinous cystadenocarcinoma 5.81±1.22 umol/L, with the difference non-statistically significant(P>0.05). The LPA of well-differentiated group in histology was 4.70±1.94 umol/L, that of moderately differentiated group 5.01±1.04 umol/L, and that of poorly differentiated group 5.99±1.36 umol/L, with the difference non-statistically significant (P>0.05). The LPA level of early-stage ovarian cancer (I + II) was 4.12±1.36umol/L, and that of advanced stage (III + IV) patient 6.23±1.07 umol/L, with the difference having statistics significance(P<0.01). The sensitivity of LPA diagnosis was up to 80% in early-stage ovarian cancer,the sensitivity of CA125 diagnosis only 50%.The difference have statistics significance(P<0.05).Conclusion: Plasma LPA has high sensitivity and specificity in diagnosing ovarian cancer. Detecting the level of plasma LPA in the patient with ovarian cancer is a simple, fast, convenient, high sensitive and specific method for diagnosing and monitoring of ovarian cancer. LPA obviously elevates, in particular, in early- stage ovarian cancer; its diagnosis sensitivity may reach 80%. Meanwhile, LPA is also a monitor index of postoperative ovarian cancer. The is a convenient, quick, non-invasive and economical detection method. It is worth the clinical promotion.
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