Association Study Between Schizophrenia And Human Frizzled 3 Gene (rs2241802,rs2323019,rs352203) Polymorphism In Yunnan Han Population

Objective To explore whether the polymorphism of human frizzled3(rs2241802,rs2323019,rs352203)is associated with schizophrenia in Yunnan Han population.Methods PCR-RELP was used to detect the polymorphism of huma frizzled3(rs2241802,rs2323019,rs352203)in 153 patients and 100controls.All patients were evaluated with PANSS. Following a linkage disequilibrium test in the 3 loci,association analysis was carried out between the polymorphism,including haplotype,and schizophrenia in all samples.Results No significant difference genotype and allele frequency of the 3 loci was observed in 2 groups There was no difference in genetype and allele frequency of rs2241802,rs2323019,rs352203 in Han samples.(P＞0.05)The polymorphism of both loci has observed no difference in case-sibling control study of normal group.A-A-C haplotype and G-A-C haplotype were observed with a significant higher frequency in both samples(P＜0.05).There was no difference in patients and controls in PANSS scores.(P＞0.05).Conclusions There is no association between polymorphism of human frizzled3(rs2241802,rs2323019,rs352203)and schizophrenia in Han.A-A -C and G-A-C haplotype may possibly associate with schizophrenia in Yunnan Han population.