The Relationship Between The Expression Of EGFR,NF-κB And The Radiosensitivity

ObjectiveTo detect the expression of EGFR and NF-κB and probe the relationship between the two factors and the radiosensitivity in human nasopharyngeal carcinoma,and then give a theory documentation that EGFR and NF-κB could be targets to sensibilize nasopharyngeal carcinoma by interfering their expression.MethodsImmunohistochemical staining SP methods was performed to evaluate the expression of EGFR and NF-κB,and the radiotherapy effect was assessed by follow-up visit and clinical judgement,and all of the NPC patients' tissues'pathological type were poorly differentiated and squamous cell carcinoma,and all of the patients had never been treated by radiotherapy,operation or other treatments.All of the patients were divided into three groups which were called the complete response-group,the partial response(or the stable disease)-group and the progressive disease-group.We detected the two factors' expression in each group.ResultsEGFR and NF-κB expressed in the human nasopharyngeal carcinoma but not in normal cells,and significant difference in the radiosensitivity had been shown on the two factors(P＜0.05).The two factors'expression in the complete response-group and the partial response(or the stable disease)-group were lower than the progressive disease-group(P＜0.05),and there was no significant difference between the complete response—group and the partial response(or the stable disease)-group(P＞0.05).The two factors'expression had negative correlation with radiosensitivity.ConclusionsEGFR and NF-κB,as important targets,could predict the radiosensitivity of NPC,which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.