The Correlation Whole-body MRI Of Bone Marrow With Vascular Endothelial Growth Factor In Patients With Acute Myeloid Leukemia

Objective: To assess the whole-body fast spin echo T1 weight imaging (FSE T1WI) magnetic resonance imaging (MRI) for detecting bone marrow in patients with acute myeloid leukemia ( AML) and to correlate the results with vascular endothelial growth factor (VEGF) plasma levels.Methods: Twenty-four patients with AML (mean age = 47 years, age range: 8–72 years) were assessed for infiltrated bone marrow with whole-body MRI and measurement of VEGF levels by enzyme linkedimmunosorbent assay (ELISA) Six parts in each patient were assessed with FSE T1WI during MRI. Whole-body MRI were compared with VEGF levels.Results: MR imaging showed that bone marrow in all patients were infiltrated by leukemia cells ,but the scope of infiltration were different among patients. MR imaging of femoral marrow were classified into three patterns according to size of infiltrated marrow in tibia. The VEGF plasma levels were from3.13 to 49.48. The correlation MRI degrees with VEGF plasma levels were significant difference (P=0.016) .Conclusion: Whole-body MRI is a reliable method for manifesting bone marrow in patients with AML . The degrees of infiltrated bone marrow were correlated with VEGF plasma levels.