Study Of MRI And ～1HMRS On Normal Middle And Distal Femoral Bone Marrow

Objectives 1. To discuss the age-related changes of signal intensity on magnetic resonance imaging (MRI) in normal middle and distal femoral bone marrow with qualitatively and quantitatively to supply normal reference for basic research and clinical diseases of bone marrow. 2. To choose proper proton magnetic resonance spectroscopic (1HMRS) parameters to fit for practical femoral marrow cavity and to produce short-timed, well producible and excellent 1HMRS. 3. To investigate spectroscopic characteristics of 1HMRS of normal middle and distal femoral bone marrow within different ages, and to reveal histological bone marrow conversion and supply normal reference for clinical bone marrow diseases.Materials and methods The prospective study of right middle and distal femoral bone marrow was performed with a Siemens Magneton Vision 1.5-T system and head coil accompanied with a single-voxel proton MR spectroscopy software. All examinations were finished after the informed consent.Firstly, thirteen normal volunteers aged 16 to 33 years in our school prospectively enrolled in the tentative study of ~1HMRS on normal femoral bone marrow. ~1HMRS parameters for 7 volunteers were TR 1500 ms/ TE 270 ms, number of acquisition was 128, and volume of interest (VOI) size was 1×1×1 cm~3 and repeated 2～3 times within the same location. 1HMRS parameters for another 6 volunteers were TR 1500 ms/TE 270 ms and different numbers of acquisition (128 and 256, respectively) and different VOI sizes ( 2×2×2 cm~3 and 1.0×1.0×1.0 cm~3 , respectively).Secondly, seventy-two cases with normal femoral bone marrow were collected between Nov. 2004 and Oct. 2005. Of these patients aged 2 to 30 years, 51 were male...