Effects Of N-3 Fatty Acids On The Regulating Of Inflammatory Mediators On Surgical Patients With Systematic Inflammatory Response Syndrome

Objective: To evaluate the effects of n-3 fatty acids on the regulating of inflammatory mediators on the surgical patient's with systemic inflammatory response syndrome(SIRS).Methods: Forty-eight surgical patients with SIRS from Aug. to Nov. in 2007 were involved in a randomized, controlled and prospective clinical trial, and divided into n-3 fatty acids group and control group. All patients were treated with routine surgical treatment combined with total parenteral nutrition (TPN). Twenty-four cases in n-3 fatty acids group were treated with n-3 fatty acids supplied by n-3 fatty acids solution 100ml, and the other twenty-four cases in control group were not given. All patients were observed for 5 days. The data of inflammatory parameter (IL-1, IL-6, IL-8, TNF-α) were detected and analyzed, respectively, 1 day before TPN and 5 days after TPN. And the acute physiology and chronic health evaluation (APACHE II) have also been respectively assessed.Results: No side effects were noted. The scores of acute physiology and chronic health evaluation (APACHE II) and the level of serum IL-1, IL-6, IL-8, TNF-αdecreased significantly in two groups (P<0.05), but the decrease in n-3 fatty acids group was more obvious than that in control group (P<0.05).Conclusion: N-3 fatty acids benfit SIRS surgical patients by reducing the excessive release of inflammatory mediators, play an important role in regulating inflammatory mediators, and reduce APACHE II, improved the prognosis of patients with SIRS, in the treatment of critically patients to play an active role, provide a new treatment methods and ideas.