Omega-3 Fatty Acids Attenuated The Inflammatory Response And Influenced The Prognosis In Severe Multiple Trauma Patients

Objective:The widespread recognition that severe multiple trauma is characterized as a state of inflammation and immunosuppression. Omega-3 fatty acids can regulate the body's inflammatory response and affect the function of immune cells.Methods:Patients (n= 42) with severe multiple trauma (injury severity scores, ISS>16) treated at our hospital's Department of Surgical Trauma between September 2008 and May 2009 were randomly divided into a control group (n=21) and Ewing group (n=21). In addition to standard treatment protocols administered to all, the Ewing group received supplementation withω-3 polyunsaturated fatty acids. Maximum temperature, white blood cell count, liver function, renal function, and blood coagulation parameters were monitored at different time points after injury. Levels of inflammatory response indicators TNF-α, IL-6, IL-8, IL-10, and C-reactive protein were obtained; and CD4/CD8 ratios and HLA-DR expression were ascertained to assess immune function. Incidence of systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF), duration of ICU stay, total length of hospital stay and mortality rates were compared. Results:Inflammatory response levels and immune function were significantly different for the two groups (P<0.01 and P<0.05, respectively). The inflammatory response in the Ewing group was significantly decreased, and immune function was improved. Better prognosis resulted for the Ewing group than the control group.Conclusion:Supplementation withω-3 polyunsaturated fatty acids can effectively regulate the inflammatory response and immune function in patients with severe multiple trauma, possibly improving prognosis.