Expression And Significance Of EIF4E, C-erbB-2 And FHIT In Pathological Scar

Objective To study the expression of eIF4E,C-erbB-2 and FHIT in the pathological scar and their probable role in the pathogenesis of abnormal scars.Methods Immunohistochemistry integrated image analysis and reverse transcriptionpolymerase chain reaction(Rr-PCR)were performed to detect the expression and distribution of eIF4E in hypertrophic scar,keloid, mature scar and normal skin.Immunohistochemistry integrated image analysis was used to detect the expression and distribution of C-erbB -2 and FHIT in the above tissue.Statistics was used to analyze the datas.Results The expression of eIF4E protein and eIF4E mRNA increased in abnormal scar(P＜0.005)and their expression was not statistically defferent between the hypertrophic scar and keloid(P＞0.05).The level of C-erbB-2 protein expression was not statistically defferent between the hypertrophic scar andkeloid(P＞0.05),while they wereall remarkably significant in comparison between normal control group and abnormal scar(P＜0.005).There was positive correlation existing between eIF4E protein andC-erbB-2 protein expression(P＜0.01).rhe expression of FHIT protein between pathological scar group and normal control group has no difference(P＞0.05).Conclusion The result indicated that the expression of eIF4E and C-erbB-2 was increased in abnormal scar.eIF4E and C-erbB-2 over-expression may play an important role in the pathogenesis of pathological scar.The expression of eIF4E positively related to the expression of C-erbB-2.The loss and depression of FHIT protein expression was not observed in abnormal scar,indicating FHIT does not contribute to the excessive scaring.