The Expression Of Serum Macrophage Migration Inhibitory Factor And Vascular Endothelial Growth Factor In Patients With Psoriasis Vulgaris.

Psoriasis is a persistent cutaneous disease characterized by skin inflammation and infiltration of immunocytes such as lymphocytes and monocytes/macrophages,concomitant with abnormal epidermal hyperproliferation.Beforehand research showed that the serum level of macrophage migration inhibitory factor(MIF),vascular endothelial growth factor(VEGF)and ther production by peripheral blood mononuclear cells of patients with psoriasis were closely correlated with psoriasis morbidity,however,the precise role of MIF and VEGF in psoriasis morbidity remains to be clarified.The current study was carried out to elucidate the possible involvement of MIF and VEGF in psoriasis.Objective:To investigate the relationship between macrophage migration inhibitory factor(MIF)and vascular endothelialgrowth factor(VEGF)and psoriasis.Methods:Serawere taken from 40 patients with psoriasis vulgaris and 17 normal controls.The serum levels of MIF and VEGF were measured by double antibody sandwich enzyme-linked immunosorbent assay(ELISA). Clinical severity of psoriasis vulgaris were assessed by psoriatic area severity index(PASI).Results:The serum MIF levels were significantly higher in patients with psoriasis vulgaris than those in normal controls (P＜0.01).And in progressive stage than those in stationary stage(P＜0.01)of psortatic patients.The concentrations of mif were significantly higher in patients of progressive stage than those in stationary stage(P＜0.01)and normal controls(P＜0.01).There was a significant correlation between serum MIF levels and PASI(P＜0.05)but not VEGF levels(P＞0.05).Furthermore,the expression of serum MIF levels and serum vegf levels have positive correlation(P＜0.05).Conclusion:The result indicate that serum MIF and VEGF levels are significantly higher in patients with psoriasis vulgaris which may be involved in the pathogenesis of psoriasis vulgaris.