Effect Of Bu Xin Qi Kou Fu Ye On Stable Angina Pectoris And On The Levels Of TNF-a And Cys C

Objective To investigate the levels of Cystatin C(Cys C)and Tumor necrosis factor-a(TNF-a) in patients with Stable angina pectoris (SAP) and the effect of the traditional Chinese medicine—Bu xin qi kou fuye.Methods Consecutive 63 patients with Stable angina pectoris (SAP) and 30 normal controls(NC group) were enrolled. Patients with Stable angina pectoris were randomly assigned to the Bu xin qi kou fu ye group (n=32) and the Nitrate group (n=31). Based on the routine treatments, including aspirin,β-blocker,statin and angiotensin-converting enzyme inhibitor (ACEI) or angiotensinⅡ-receptor blocker(ARB), the Bu xin qi kou fu ye group were treated with Bu xin qi kou fu ye and the nitrate group with Nitrosorbie or Isosorbide mononitrate for 12 weeks. Before and after treatment, the clinical symptom and quality of life were evaluated. Peripheral blood was obtained from NC group when first engaged and from patients with Stable angina pectoris before and after the treatment. The level of serum Cys C and TNF-a were compared between patients with Stable angina pectoris and NC group, and before and after intervention with drugs.Results (1) The total symptomatic effective rate of angina pectoris in Bu xin qi kou fu ye group was 81.3%, which was higher than 54.8% in the Nitrate group (P =0.024) ; (2) The stop-decrease rate of nitroglycerin was 75.0% in Bu xin qi kou fu ye group, which was higher than 48.4% in Nitrate group (P =0.030) ; (3) The total ECG effective rate was 59.4% in Bu xin qi kou fu ye group and 61.3% in the Nitrate group .There were no obvious differences between them(P =0.877); (4) The improvement of quality of life in Bu xin qi kou fu ye group was superior to Nitrate group after treatment (P <0.05) ; (5) Before treatment, serum level of TNF-a in patients with Stable angina pectoris was higher than those in NC group,and the concentration of Cys C was lower than in NC group (P<0.05) ,while there was no significant difference between Bu xin qi kou fu ye group and Nitrate group. After treatment, the level of serum TNF-a in Bu xin qi kou fu ye group was significantly lower than those in Nitrate group and before treatment, whereas the concentrations of Cys C were higher than those in NC group and before treatmen (P <0.05) . The extent of changes in Bu xin qi kou fu ye group was bigger than in Nitrate group (P<0.05).Conclusions 1. Bu xin qi kou fu ye remarkably improved the symptoms and quality of life of patients with Stable angina pectoris, and should be taken as an effective drug for Stable angina pectoris. 2. High level of TNF-a and low level of Cys C were present in patients with Stable angina pectoris, and level of Cys C was elevated and the concentration of TNF-a decreased after treatment of Bu xin qi kou fu ye, which indicated that Bu xin qi kou fu ye was available to anti-inflammation.