The Detection And Significance Of SICAM-1 And STM In Patients Of Antiphospholipid Syndrome With Spontaneous Abortion

Objects:To detect the concentration of soluble intercellular adhesion molecule-1(sICAM-1)and soluble thrombomodulin protein (sTM)in patients of antiphospholipid syndrome with spontaneous abortion,research their role of the pathogenesis of antiphospholipid syndrome.Methods:The serum samples,which were obtained from the study group,composed of 40 APS patients with spontaneous abortion,from the control groupⅠ,composed of 33 non- APS patients with spontaneous abortion,and from the control groupⅡ,composed of 20 normal women, were measured by Enzyme-Linked immunosorbant assay for ACA,aβ2GPⅠ,sICAM-1 and sTM.Plasma viscosity was measured by automatic-hemorheologic machine.Results:(1)SICAM-1 concentration of the study group,the control groupⅠandⅡwere 338.49±14.88 ng/ml,259.50±14.17ng/ml and 253.51±13.12ng/ml,sTM concentration in these three groups were 22.07±2.28ng/ml,14.15±0.90ng/ml and 14.06±1.30 ng/ml.The study group demonstrated significantly higher concentration of sICAM-1 and sTM than that of the control groupⅠandⅡ(P＜0.001).Between the control groupⅠandⅡ,there have no significant difference(p＞0.05)(2)In ACA positive patients of the Study Group,ACA,sICAM-1 and sTM concentration was 16.27±2.93u/ml,341.45±16.65ng/ml and 22.60±2.58 ng/ml.The Pearson correlation coefficient between ACA and sICAM-1,sTM was 0.467(P＜0.05),0.503 (P＜0.01).The relationship of ACA and sICAM-1,sTM is positive correlation.In aβ2GPⅠpositive patients,aβ2GPⅠ,sICAM-1 and sTM concentration was 11.40±1.56 u/ml,343.69±14.67 ng/ml and 22.67±2.15 ng/ml.The Pearson correlation coefficient between aβ2GPⅠand sICAM-1,sTM was 0.835(P＜0.001),0.859(P＜0.001)The relationship of aβ2GPⅠand sICAM-1,sTM is positive correlation.(3)In the study group,the Pearson correlation coefficient between sICAM-1 and sTM concentration was 0.799(P＜0.001),the two are positive correlated.The plasma viscosity was 1.86±0.16 mPa-s,which demonstrated higher concentration than that of the control groupⅠandⅡ(P＜0.001).The Pearson correlation coefficient between sICAM-1 and plasma viscosity was 0.669(P＜0.001),the two are positive correlated.(4)In the study group,ACA,aβ2GPⅠ,sICAM-1,sTM concentration and plasma viscosity of before treatment was 13.08±5.04 u/ml,9.59±8.7 u/ml,338.49±14.88 ng/ml,22.07±2.28ng/ml,1.86±0.16 mPa·s;,and of after treatment was 6.93±2.10 u/ml,5.04±1.74 u/ml,276.91±7.35 ng/ml,16.13±1.76 ng/ml,1.63±0.05mPa·s.The group after treatment demonstrated significantly lower concentration of each than the the group before treatment(P＜0.001).Conclusions:(1)SICAM-1 and sTM correlate with APS.They may cause blood hypercoagulability.(2)SICAM-1 and sTM can be used as a severity index of APS.