| The first departmentObjective: To observe the clinical curative effect of treating diarrhea predominant irritable bowel syndrome with Danggui Shao- yao powder and Sini powder and the influence of quality of life.Method: The case-control study was adopted. The selected cases according to"Randomized Number Scale"were randomly divided into two groups: 68 patients in treatment group were administered with Danggui Shaoyao powder and Sini powder; 54 patients in control group were administered with Dicetel. Both groups were treated for four weeks. Clinical symptoms'changes, effect on quality of life before and after treatment were detected respectively to evaluate the therapeutic effects.Result:(1)Clinical symptom therapeutic effect: In treatment group the total efficiency is 89.71%,which is significantly higher than that of control group(P<0.01).In control group the total efficiency is 68.52%. (2) Compared the main clinical symptom before and after treatment: All the main clinical symptoms were markedly improved after treatment in treatment group, while only diarrhoea,abdominal pain and distention and rugitus were improved after treatment in control group(P<0.01). There was a significantly difference between treatment group and control group after treatment in diarrhoea,abdominal pain and distention,painful abdominal mass and tired(P<0.05). (3) Compared the observation indexs of quality of life before and after treatment: There were markedly improved after treatment in treatment group in emotional state,energy,society role,work, mental status and food and drink,w- hile only emotional state and energy were improved after treatment in control group. There was a significantly difference between treatment group and control group after treatment in emotional state,mental status ,food and drink and society role(P<0.05). (4)Compared prostecdtive efficacy:The recurrence rate in treatment group was 15.0% while in control group was 36.4%.There was a significantly difference between two groups.(5)Evaluate therapeutic safety in the two groups: There were neither obvious changes in blood, urine or stool rules before and after treatment nor in Electrocardiogram or liver-renal function. In the course of the treatment, all patients had no undesirable response, which pointed the fact that treatment group and control group have no toxic and side effect.Conclusion: The study indicates that Danggui Shaoyao powder and Sini powder can improve patient's clinical symptom, sublimate quality of life, decrease the recurrence rate of diarrhea predominant Irritable Bowel Syndrome. Its curative effect is better than that of Dicetel. The research from clinical curative effective aspect approves that Danggui Shaoyao powder and Sini powder is feasible and practicable in treating diarrhea predominant Irritable Bowel Syndrome.The Second DepartmentObjective: To explore mechanism of Danggui Shaoyao powd- er and Sini powder in treating diarrhea predominant irritable bowel syndrome by constructing animal model.The aim is to provide experimental evidence for clinical research.Method: 40 healthy male Wistar rats were selected and rando- mly divided into five groups:normal group,model group, Dicetel group, low dose group , large dose group ,each group had 8 rats. Rat models of diarrhea predominant irritable bowel syndrome were established by senna leaves and wrap restraint stress method. 24 hours after the operation, the amount of dried medicinal herb given to large dose group and low dose group was 31.6g/kg weight and 15.8g/kg weight respectively. The amount of Dicetel given to Dicetel group was 30mg/kg weight. The normal saline was given to normal group and model group, respectively.The degree of Loose stools and body weight were observed before and after treatment. Two weeks later, 50% charcoal suspension lavaged, all rats were killed to observe following index after 20min: small intestine charcoal suspension pushing rate,motilin, vasoactive intestinal peptide,somatostatin, pathology of bowel mucosa tissue.Result:(1) Compared the degree of Loose stools before and after treatment: The degree of Loose stools before one day treatment in model group,Dicetel group,low dose group and large dose group was markedly heightened than that of normal group(P<0.01). The degree of Loose stools after fourteen day treatment in large dose group was markedly decrease than that of Dicetel group and low dose group(P<0.01).(2) The change in body weight: Compared with normal group,the body weight of other rat groups was all lighten after model (P<0.01).Compared with normal group, the body weight of model group was markedly lighten after treatment (P<0.01). There were no significantly difference among the rest groups.(3)Compared the small intestine charcoal suspensio- n pushing rate:Compared with normal group, model group,Dicetel group and low dose group could increase charcoal suspension pushing rate(P<0.01), especially model group. There were no significantly difference between large dose group and normal group. (4)The contents of MOT in blood plasm:Contents of MOT in Dicetel group,low dose group and large dose group was all decreased than that of model group(P<0.05), especially large dose group. (5) The contents of VIP in blood plasm:Contents of VIP in Dicetel group,low dose group and large dose group was markedly decreased than that of model group, especially large dose group. (6) The contents of SS in blood plasm: Contents of SS in large dose group was markedly decreased than that of model group(P<0.01). Compared with Dicetel group, large dose group could significant decrease the Contents of SS (P<0.05). (7)Observation of bowels mucosa tissue:The bowels mucosa tissue of rats was not found apparente inflammatory pathological changes。Conclusion: The mechanism of Danggui Shaoyao powder and Sini powder in the treatment of IBS was to adjust the disordered secretion and release of gastrointestinal hormones,such as MOT, SS,VIP, and form apparente dose-effect in large dose.
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