Effert Of Moist Keeping Drugs For External Use On Differentiation And Migration Of Epidermal Stem Cells In Rat Deep 2^nd Degree Burn Injury Skin

Burn injury often happens in life. After being wounded, the main treatment focus on burned skin is to prevent infection and use drugs which can help wound healing. The key of whole body treatment is to reduces the MODS incidence rate and mortality by prevent and cure SIRS. There are two concepts on managing burn injury skin at present, the traditional viewpoint is using dry astringeing and antibacterial medicine to cover the injured area which can keep the wounded area dry and prevent infection. In recent years,there is another viewpoint that is Moist exposed burn treatment (MEBT). The key of MEBT is to maintain physiological moist microenvironment by external using medicine which would provid physiological condition for wound healing. Regardless of using which treatment,epidermal stem cells play a important role in the process of burned skin wound healing.We applied MEBT to treat burned skin with two external using medicines (MEBO,silvasorb) And observed the differentiation and migration of epidermal stem cells in rat partial-thickness burn injury skin during its healing process,and investigate the relevance between ESCs and healing quality. This experiment indicate that moist keeping drugs for external use can increase the quantity of epidermal stem cells, can promote its differentiation and migration, and can reduce injured area infection and help injured area healing. All of these aspects are much better than control group(P<0.05). Between therapy groups, the infection rate, quantity of ESCs, burned skin healing rate were no statistically significance(P>0.05). The results of this experiment provid certain theory basis to the mechanism of MEBT helping burn injury skin wound healing.