Pharmacodynamics Of Action Study Of Aucklandia Lappa Decne In Treating Experiment Gastric Ulcer

Gastric ulcer(GU)is a frequently-seen disease in clinic.China is among the areas of high incidence.Several clinical studies show that GU is quite damaging to the workforce.At present,the pathological mechanism how GU happens is not complete known yet.It is generally considered that it is the result of the imbalance between the protective factors and damaging factors of the mueosa.This subject aims to observe if extracts of Aucklandia lappa Decne(EOALD)has the effect of anti-ulcer and initial discuss its possible effective mechanism through ancient and modern document investigation and animal testing investigation.The document research shows that the pathogenesis of gastric ulcer mostly relates to injuries for improper food or drink,emotional disturbances,fatigue and so on All sorts of reasons due to the decline of splentic functions together with the cold syndrome.In TCM therapeutics,warming the middle-warmer,invigorating spleen, circulation Qi,restrain acid regularly proves effective.Duplicate rat Gastric ulcer model by means of water immersion stress method,acetie acid daub method,pyloric deligation method and Indomethaein method.Approach the extract of Aucklandia lappa Deene anti-ulcerative mechanism of action based on pharmacodynamics.Observe the restrained function of the extract of Aucklandia lappa Decne for every GU model,the capacity and the total acidity of gastric juice,the pepsin activity,the content of NO and MDA in the gastric mucosa.The result demonstrates that aqueous extracts of Aucklandia lappa Decne(AEOALD)has some treatment and prevention effect on acute and chronic rat GU model making by all kinds of ways.It can reduce the excretive quantity of the rat's gastric juice,decrease the level of total acidity and pepsin activity,increase the contents of NO in gastric juice.It has the trend that can descend the contents of MDA in gastric tissue,but don't manifest the statistical meaning.The ethanol extracts of Aucklandia lappa Decne don't manifest the function of anti-ulcer.It is speculated that AEOALD may produce effect through both inhibiting damage factor and enhancing defefnd factor.This study provides experimental evidences for preventing,and treating peptic ulcer clinically of EOALD and possesses certain reference value for directing the application of drugs to preventing and treating peptic ulcer and developing new drugs.