Clinical Study On Relationship Between TCM Blood Stasis Syndrome Of Type 2 Diabetes Mellitus And Carotid Intima-media Thickness

Objective:The aim of this study was to explore the relationship between TCM blood stasis syndrome of type-2 diabetes mellitus and carotid intima-media thickness and provide an instruction for prevention and cure to macroangiopathy of type-2 diabetes mellitus by Chinese medicine of promoting blood circulation to remove blood stasis.Objects and Methods:According to the WHO(1999) diagnosis standard,79 type-2 diabetes mellitus patients were chosed as research objects.Then according to 2002 "Chinese Native Medicine New Medicine Clinical Research Guiding Principle" blood stasis card diagnosis standard,79 type-2 diabetes mellitus patients were divided into TCM blood stasis syndrome group and non-blood stasis syndrome group,including 37 males,42 females age from 37-88 years old.The average age was 62.71±10.52 years old and the average course of illness was 7.42±7.11 years.After the patients were brought into the research team,according to 2002 "Chinese Native Medicine New Medicine Clinical Research Guiding Principle" the marking standards for blood stasis and "Marking Standards for Blood Stasis Diagnosis" of Jie Wang and Keji Chen,a card was designed to value the blood stasis of 79 cases. Ultrasonography of carotid intima-media thickness was performed using a high frequency linear array transducer.The results of carotid intima-media thickness were analyzed in two groups' patients.The carotid intima-media thickness was compared with the scores of blood stasis.Results:1.Blood stasis syndrome group 49 cases,the average score of blood stasis was 25.37±7.84(12-45),non-blood stasis syndrome group 30 cases,the average score of non-blood stasis was 5.70±3.28(0-11),the scores of blood stasis syndrome group were significantly higher than the scores of non-blood stasis syndrome group,P＜0.001.2.The average carotid intima-media thickness of all cases was(1.08±0.25)mm,the average carotid intima-media thickness of blood stasis syndrome group was(1.173±0.250)mm,the average carotid intima-media thickness of non-blood stasis syndrome group was(0.930±0.167)mm. The carotid intima-media thickness of blood stasis syndrome group was higher than the carotid intima-media thickness of non-blood stasis syndrome group,P＜0.05.3.There was positive correlation between the scores of 79 type-2 diabetes mellitus and the carotid intima-media thickness,P＜0.001.Conclusion:1.The carotid intima-media thickness of blood stasis syndrome group was higher than the carotid intima-media thickness of non-blood stasis syndrome group,P＜0.05.It implies that the carotid intima-media thickness may be the index to monitor TCM blood stasis card.2.There was positive correlation between the scores of type-2 diabetes mellitus and the carotid intima-media thickness.It implies that the blood stasis of type-2 diabetes mellitus may be the risk factor of the carotid intima-media thickness increase and using the method of promoting blood circulation to remove blood stasis is possibly helpful to prevent and cure macroangiopathy of type-2 diabetes.