Clinical Study On Relationship Between The Syndrome Types Of TCM And Clinical Subtypes, MRA, The Serum Level Of Homocysteine And Blood Lipid, Intelligence Obstacle, Depression In CI

Objective:To study the relationship between the syndrome types of TCM and clinical subtypes,MRA,homocysteine(HCY),blood lipid and the other correlative index in cerebral infarction.Methods:According to diagnostic criterion of western medicine and criterion of exclucive case,68 cases with cerebral infarction were selected and classified into the wind syndrome(WS),phlegm syndrome(PS),blood stasis syndrome(BSS),qi deficiency syndrome(QDS) and 15 cases of healthy people were selected as the normal control group(NCG).The 4 different types of TCM of cerebral infarction were compared with eatch other by clinical subtypes,MRA,HCY,blood lipid and the other correlative index,and then were compared with the normal control group,observing the change of index to study the relationship.Results:⑴comparison of clinical subtypes of cerebral infarction in the syndrome types of TCM:①The level of atherothrombotic cerebral infarction(ACI) of 4 groups is as follow: WS > PS > BSS > QDS,the level of ACI of WS is higher than QDS,the difference was very significant (P<0.05); There was not a significant difference among the WS, PS and BSS(P>0.05).②The level of cerebral embolism (EI) of 4 groups is as follow: PS > BSS > WS > QDS ,the level of EI of PS is higher than QDS,the difference was very significant (P<0.05); There was not a significant difference among the WS, PS and BSS(P>0.05).③The level of lacunar embolism (LI) of 4 groups is as follow: QDS > BSS> PS > WS, the level of LI of WS and PS is higher than QDS,the difference was very significant (P<0.05, P<0.05);There was not a significant difference among the WS,PS and BSS(P>0.05).④The level of cerebral watershed infarction(CWSI) of 4 groups is as follow: QDS > BSS > PS and WS, the level of CWSI of WS and PS is higher than QDS,the difference was very significant (P<0.05, P<0.05); There was not a significant difference among the WS, PS and BSS(P>0.05).⑵comparison of MRA in the syndrome types of TCM: The level of the number of vascular stenosis of 5 groups is as follow: BSS > WS > QDS > PS > NCG, the level of the number of vascular stenosis of WS,PS,BSS and QDS is higher than NCG,the difference was very significant (P<0.01);PS was much higher than BSS, the difference was very significant (P<0.01); BSS was higher than WS and QDS, the difference was significant (P<0.05);but the difference between WS and PS was not very significant (P>0.05).⑶comparison of the 5 groups'HCY: The level of HCY of the groupis as follow: PS > WS > BSS > QDS > NCG, the level of HCY of PS,WS and BSS is higher than NCG, the difference was very significant (P<0.01); QDS was higher than NCG(P<0.05);WS and PS is higher than BSS, the difference was very significant (P<0.05)and WS ,PS and BSS is higher than QDS(P<0.01,P<0.05,P<0.05);but the difference between WS and PS was not very significant (P>0.05).⑷comparison of the 5 groups'blood lipid:①The level of TG of 5 groups is as follow: PS > WS > BSS > QDS > NCG, the level of TG of PS,WS and BSS is higher than NCG, the difference was very significant (P<0.01);but the difference among PS,WS,BSS and QDS was not significant(P>0.05).②The level of TC of 5 groups is as follow: PS > BSS > WS > QDS > NCG, the level of TG of PS,WS and BSS is higher than NCG, the difference was very significant (P<0.05);but the difference among PS,WS,BSS and QDS was not Significant (P>0.05).③The level of LDL of 5 groups is as follow: WS > PS> BSS > QDS > NCG, the level of LDL of PS and WS is higher than NCG, the difference was very significant (P<0.01 ,P<0.05); WS is higher than QDS and BSS (P<0.05); but the difference between WS and PS was not very significant (P>0.05).④The level of HDL of 5 groups is as follow: NCG > QDS > BSS > PS > WS, the level of HDL of NCG is higher than WS and PS, the difference was very significant (P<0.01,P<0.05); QDS and BSS were higher than WS (P<0.01,P<0.05); but the difference between WS and PS was not very significant (P>0.05).⑸comparison of the 5 groups'depression score: The level of depression score of 5 groups is as follow: WS > PS > BSS > QDS > NCG, the level of depression score of WS ,PS and BSS is higher than NCG, the difference was very significant (P<0.01); WS and PS were higher than BSS and QDS (P<0.01); but the difference between WS and PS was not very significant (P>0.05).⑹comparison of the 5 groups'intelligent scoring:The level of intelligent scoring of 5 groups is as follow: NCG > QDS > WS > BSS > PS, the level of depression score of WS ,PS ,BSS and QDS is higher than NCG, the difference was very significant(P<0.05);but the difference among WS ,PS ,BSS and QDS was not significant(P>0.05).Conclusion:⑴The relationship between the syndrome differentiation of TCM and clinical subtypes,HCY,blood lipid with cerebral infarction is clear.They may offer objective reference to syndrome differentiation of TCM of cerebral infarction.⑵MRA can serve as a reference index in microcosmic syndrome differentiation of TCM in BSS.⑶Depression can serve as a reference index in microcosmic syndrome differentiation of TCM in WS,PS,and to guide clinical Interference early.It can reflect the thought of"preventive treatment of disease"of TCM.