The Study Of Orally Disintegrating Tables Of Herba Cirsii

Herba Cilsii is one of the common hemostatics in clinical application.The major active components in Herba Cirsii are caffeic acid and chlorogenic acid,and the total flavonoids have a good effect of blood coagulation promoting and eliminate inflammation.Herba Cirsii oral rapid disintegrating tablets are suitable for aged or young people and patients with dysphagia symptom who are inconvenient in taking medicine.We carried out the investigation and exploitation on oral rapid disintegrating tablets for clinical application.After comparisons between three extraction methods,with the content of caffeic acid, chlorogenic acid and the total flavonoids as consideration indexes,we eventually chose the ultrasonic waves extraction method:The research of extraction technology is based on direct cross experiment of particle size of Herba Cirsii,alcohol multiple and extraction frequency:fixed conditions were as follows:50 kHz ultrasound magnetic field oscillations from 40 min,ethanol concentrations were 50%,the temperature controlled at 45℃.Thus selected for the extraction of the best:smash the heads of more than 40 screen Herba Cirsii,with 50 times the amount of 50% ethanol extracting twice.Getting Herba Cirsii oral disintegrating tablets with the method of powder direct compression,prescription screening test method using orthogonal to the collapse of tablets and 30 seconds before the time of dissolution of the selection indicators,by the weight of 70%,30%,the calculation of the composite score.Optimization from the prescription:a ratio of 8:2 of microcrystalline cellulose(MCC) and low hydroxyl replace L-HPC for the 45%crosslinked sodium CCNa 2%PVPP of 8%.The HPLC was used to establish the method of Herba Cirsii extracting for hemostasis effective components of chlorogenic acid,caffeic acid content determination.The method has high sensitivity,simple operation,specificity,and with the use of a mobile phase with the detection wavelength,the simultaneous determination of chlorogenic acid and caffeic acid content, results showed that:chlorogenic acid in the 0.004-0.064 mg/mL between the lines good Linear relationship;caffeic acid in the 0.1-1.2μg/mL linear relationship was good.Using UV spectrophotometry Herba Cirsii extract of the content of flavonoids.The results showed that: Rutin in the 0.04-0.2 mg/ml linear relationship between good and tablets for extraction of Determination.We had a pharmacodynamic test results of the study show that:Herba Cirsii's hemostasis effect mainly through local vasoconstriction,and the promotion of platelet aggregation,shorten the bleeding time,activated partial thromboplastin,inhibiting fibrinolysis and play a role.The results showed that Herba Cirsii oral rapid disintegrating tablet in the oral cavity can be quickly collapsed,peaking time in body is short,and better than ordinary tablets,oral disintegrating tablet can play first aid,available role.Development of the preparation,not only for the clinical application of Chinese medicine,providing a convenient,but also adds a new type of oral rapidly disintegrating agents.