| Objective To investigate the level of adiponectin,oxidative stress,microinflammation and malnutrition on the patients of every stage of chronic kidney disease(CKD),and analyze their correlativity.Methods Without infection,wound,cardiocerebrovascular events,diabetes and albuminuria, 20 of every stage of CKD(following the K/DOQI guide) patients were enrolled in the study.20 of tumor patients with normal renal function were enrolled as disease control group.20 of health adults were enrolled as normal conctrol group.The serum levels of adiponectin(APN),Interleukin-6 (IL-6),hs-C-reaction protein(hs-CRP) were measured by enzyme linked immunosorbent assay (ELISA).The serum level of Malondialdehyde(MDA) was tested by thio-barbituric acid(TBA),and tested levels of BUN,Cr,Alb,Pro-Alb,TG,CH,HDL,LDL,Lp-a and HB.Subjective global assessment of nutritional status(SGA) was used to evaluate patients'nutritional status.SPSS15.0 statistics software were applied to analyze the data.Result The levels of APN,hs-CRP and MDA in each CKD group were higher,and the serum ALB concentration was lower,compared with those of normal control group(P＜0.05 or P＜0.01).The levels of IL-6(CKDⅢ～Ⅴgroup)were higher and the levels of Pro-ALB(CKDⅣandⅤgroup) were lower,compared with normal control group(P＜0.01).There was no difference between all the groups in SGA,but the degree of malnutrition was higher and higher.There were positively correlations between APN,IL-6,hs-CRP and MDA(r=0.215～0.515,P＜0.05 ),and negatively correlation between APN,IL-6,MDA and HB,ALB,Pro-ALB(r=-0.203～0.614,P＜0.05).Conclusion 1.There are high APN and oxidative stress,microinflammation,malnutrition in all stages of CKD development,and it become higher and higher,following renal function' decrease.2. Oxidative stress,microinflammation and malnutrition form an dangerous environment for cardiovascular events.3.In the environment,APN reactively increase,and oxidative stress,microinflammation,malnutrition are the main causes. |
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