Analyze The Relationship Of Serum Levels Of Mannose Binding Lectin With Systemic Lupus Erythematosus

Objective To detect the serum levels of mannose binding lectin (MBL) in systemic lupus erythematosus(SLE) patients and healthy volunteers and to analyze its correlation with clinical symptoms,classical serum makers and disease activity indices in Chinese SLE patients ,and to explore the role of MBL in the pathogenesis of SLE.Methods ELISA was used to analyze the serum levels of MBL in 54 SLE patients (39 active and 15 inactive cases) and 45 healthy volunteers.The serum levels of anti-dsDNA antibody,complement C3,leucocyte count and circulating immune complexes(CIC) were also determined.At the same time,the main clinical symptoms of SLE patients were registered. The activity of SLE was valued by SLEDAI.Results The serum levels of MBL in SLE patients were significantly lower than those of healthy volunteers (P<0.01) ,especially the active cases,compared with those of healthy volunteers(P<0.01)and inactive cases(P<0.01) ; The serum levels of MBL in inactive SLE patients were lower than those of healthy volunteers (P<0.05) ;Serum levels of MBL in SLE patients were shown to correlate inversely with SLEDAI,CIC and anti-dsDNA antibody, and correlate positively with the levels of complement C3 and leucocyte count. Serum MBL levels in SLE patients with the kidney and the nervous system involvement and severe infections were significantly lower than those not involved.Conclusion The serum levels of MBL in SLE patients were significantly lower than those of healthy volunteers .Serum MBL level correlates intensively with the condition of SLE patient and lower serum MBL level increases the risk of the incidence of SLE. Serum MBL level can provide reference for the judgment of the prognosis and it may be a potential biomarker of disease activity in SLE patients.