Expression Of Sex Hormone Receptor In Thyroid Papillary Carcinoma And Its Clinical Significance

Objection To investigate the relationship between the expression of the estrogen receptor(ER).Progestogen receptor(PR) in thyroid tumors tissue and tumor size,differentiation and metastasis,age,sex.Methods 60 cases of thyroid tumors,including 45 cases of papillary carcinoma and 15 cases of thyroid adenoma.Were subjected to detect ER and PR by using immunohistochemical SP method.Result:The positive rates of ER in the papillary carcinoma,the thyroid adenoma,and nomal thyroid tissue were 75.56% (34/45),33.33%(5/15) and 10.00%(1/10),The positive rates of PR were 60.00% (27/45),26.67%(4/15) and 10.00%(1/10).The positive rate of ER and PR in papillary carcinoma of the thyroid was significantly higher than those in the thyroid adenoma (χ~2=8.815,5.5006;P＜0.01,0.05) and the normal thyroid tissue(χ~2=15.1948,8.1845 P＜0.01).The positive rate of ER and PR in female with papillary carcinoma was significantly higher than that in male(χ~2=7.3049,P＜0.01 ),and that in those aged less than 45 years was significantly higher than that in those aged more than 45 years (χ~2=6.5366,P＜0.02).But the expression positive rate of PR in thyroid papillary carcinoma did not relate to age and sex.The expression positive rate of ER in cases with high differentiation were higher than that in cases with low differentiation (χ~2=4.6650,P＜0.05 ).The expression positive rate of ER and PR in cases without lymph node metastasis were higher than that in cases with lymph node metastasis (χ~2=4.4466,11.5200;P＜0.05,0.01).Conclusions The expression of ER and PR in papillary carcinoma of the thyroid was higher than those in the thyroid adenoma and in the nomal thyroid tissue,the result suggested that ER and PR may be concerned with the forming procession of papillary carcinoma of the thyroid;The positive rate of ER in the younger(＜45years) of papillary carcinoma was higher than that in the older(≥45years).The positive rate of ER in female with papillary carcinoma of the thyroid was higher than that in male.The result suggested that The papillary carcinoma of the thyroid may be a kind of estrogen-dependent tumor.The treatment with hormone inhibitor may be effective;The ER positive rate in high differentiation carcinoma was higher than that in low differentiation carcinoma.That implied the expression of ER was a reference index of the differentiation degree in thyroid papillary carcinoma;The expression positive rate of ER and PR in cases without lymph node metastasis were higher than that in cases with lymph node metastasis,that may indicate the expression of ER and PR was a reference index of the forecasting the stste of lymph node metastasis in the papillary carcinoma of the thyroid.