| The Thoraco-abdominal Injury often causes the instability of organism hemodynamics, it not only caused by the cardiac functional impairment involved in trauma itself including heart and lungs, but also have close relationship with the secondum organ detriment caused by multitude cytokine released after trauma, it also the nodus of clinic remedy and the main death causing.So, precaution and nonage management of treating secondary lesion caused by disord of blood circulation and disequilibrium of inflammatory factor are the key point of clinic remedy. There years, the research have discover that the calcitonin gene-related peptide(CGRP)have intensive angiectasia effect,and could suppress the release of vasoconstriction factor post-traumatic, blocking peroxidatic reaction in vivo, and have protection effect to the injured cardiac muscle at the same time. In this study,we investigate and analyze the effect of extrinsic CGRP (calcitonin-gene-related peptide) on the cardiac function of rabbits with impact injury on processus xiphoideus.Methods:To injure thirty adult rabbits (male or female) on their processus xiphoideuses with BIM-IV biological impact machine and divide them into three groups. Group A is treated with intravenous hysiological saline, group B with intravenous CGRP (CGRP 0.012μg /kg), and group C with CGRP in large doses(CGRP 0.024μg /kg). To measure the LDH , CK, CE after injury respectively; to measure the exponent of MDA, the activity of SOD of myocardial tissues, and the data of intracellular dissociated calcium ion in the heart of the dead rabbits, while observing the pathological change and analysis the traumatic condition .The main outcomes of this research are:1. The model of LII in animals has the advantages of simple manipulation of impacting equipment, controllable physical parameters and accuracy and repeatability in impacting sites. The pathology, type and wound state of the LII in the animals are similar to those seen in clinical practice. They are in the range of gradeⅢto grade V according to AAST grading standards and 3~5 points in accordance with the AIS scoring. And LII is complicated with costal fracture and injury of the heart and lungs,conform to the stander of multiple injury. The model can be used for analysis of dynamic factors, detection of many indices. The gross anatomy, death rate and death rate change had no significant variability in three group.2. The LDH,CK,ET data of each group before injury is almost the same (P>0.05).After injury, group B and group C is lower than that of group A (P<0.01), C is lower than that of group B (P<0.01). So, the CGRP can dose-dependent attenuated the serum LDH,CK,ET level.3. MDA exponent of group B and C is lower than that of group A (p<0.01), and that of group C is lower than that of group B (p<0.05). and SOD activity group B and C is higher than that of group A (p<0.01), and that of group C is higher than that of group B (p<0.05). To compare the exponent of intracellular dissociated calcium ion in the heart of each group, and that of group C is much lower than that of group A (p<0.01), group C lower than group B (p<0.01).4.CGRP calcitonin-gene-related peptide can effectively protect the cardiac muscle from injury. It probably functions by preventing ET from rising, balancing the activity of SOD and exponent of MDA, and preventing the leak-out of CK and overloading of calcium ion in cardiac muscle.
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