Combined ¹³¹I-chTNT And External Irradiation For Solid Tumors In The Mouse

Objective: To compare the difference of only 131I-chTNT and combined 131I-chTNT and external irradiation for solid tumors in the mouse . Methods: chTNT-3, a chemic monoclonal antibody directed cell nucleus in thenecrotic parts of tumor, can play important roles in many tumors. chTNT-3 is iodinated with 131I. Among twenty-four nude mice with tumor cells xenografts(human adenocarcinoma of lung) used in the study ,were divided into six groups and given different treatment protocols. Total accumulated dose, 24h percentage of injected activity per gram of tumor tissue and accumulated dose per injected activity were compared between there different groups.Results: In the study, better yields in terms of total accumulated dose, 24h percentage of injected activity per gram of tumor tissue and accumulated dose per injected activity were seen in the first group.Conclusions: Enhanced effects can be achieved by combined external irradiation with radioimmunotherapy using the monoclonal anticytokeratin antibody 131 I-chTNT. 20Gy of external irradiation should be given prior to Mab injection.