Measurement Of Peripheral Blood CD4~+CD25~+ Regulatory T Cells And Analysis Of Correlation Between Its Proportion And The Level Of PGE2 In Patients With Bladder Cancer

Objective: To evaluate the clinical significance of PGE2 levels and the proportion of CD4+CD25+ regulatory T cells in patient with bladder cancer, to investigate the correlation between its proportion and the level of PGE2Methods: Radio immunoassay was used to evaluate plasma PGE2 levels and Flow cytometry was used to detect the proportion of CD4+CD25+ regulatory T cells in patient with bladder cancerResults: The population of CD4+CD25+T cells in peripheral blood from patients with bladder cancer accounted for (28.64±4.60)% of the total amount of CD4+ T lymphocytes, and was significantly higher in comparison with that in healthy volunteers(7.13±1.71)%(p<0.01).the CD4+CD25+ T cells population in bladder cancer patients was positively correlated with PGE2 level(r=0.73,p<0.01)Conclusion: The CD4+CD25+ regulatory T cells in peripheral blood of patients with bladder cancer is significantly increased in comparison with that in healthy subjects. It may be responsible for suppression in bladder cancer patients, and PGE2 may be an important promoting agent.