Application Of Vascular Echo Tracking Technology Evaluation Of Alcohol On Endothelial Function

At present, the field of medicine in the world, caused by a variety of alcohol has become a more serious public health problems. Drinking on blood lipids, platelet aggregation, vascular cavity shape, all affect, alcohol misuse can be caused by changes in blood rheology, microcirculation, and arterial thrombosis, such as lumen stenosis. With the incidence of cardiovascular diseases increasing, study on alcohol impact on the cardiovascular system has attracted more and more attention.Vascular endothelial cells (VEC) is an important component of the vascular system, is the barriers between blood and tissue ,with a variety function of physiological and metabolic. Vascular endothelial and vascular tone in the maintenance of the structure, regulation of coagulation and fibrinolysis, involved in inflammation and immune response mechanisms, regulation of vascular cell proliferation, white blood cell and platelet adhesion to the endothelial surface, and lipid peroxidation and vascular permeability and so play an important role. Human vascular endothelium is also very important endocrine gland, Endothelial dysfunction, with endothelial-derived relaxing factor and the contraction factor of the imbalance between secretion of regulatory function, and a serious threat to human health of several common diseases, Such as atherosclerosis, myocardial ischemia, hypertension and other cardiovascular diseases and cancer, autoimmune diseases are closely related. Endothelial cells to maintain the integrity of the normal vessel wall structure and function is extremely important, and vessel wall disease is the occurrence of cardiovascular and cerebrovascular diseases and the basis for the development. Therefore, the early vascular changes in the structure of vascular endothelial function that is carried out active and effective early detection can prevent and delay the cardiovascular and cerebrovascular disease and development.Alcohol impact on the mechanisms of endothelial cell function are: Make alcohol in the blood flow in vascular shear stress is too large, resulting in increased vascular permeability and endothelial cell damage, which affects vascular endothelial function; Alcohol can damage endothelial cells by the synthesis and secretion of vasoactive substances in the balance between the influence of calcium ion transport, so that the concentration of intracellular free calcium increase, thereby increasing peripheral vascular resistance, vascular endothelial damage; Alcohol can damage thromboxane (TXA2) and prostacyclin (PGI2) concentrations the proportion of balance to increase platelet adhesion and aggregation, endothelial cell injury and affect endothelial function; High concentrations of alcohol can leads to swelling of endothelial cells, the disappearance of three-dimensional sense, collapse into a flat shape, the disappearance of intercellular connections; Alcohol also induced apoptosis of endothelial cells, endothelial dysfunction is also an important factor.In this study, vascular echo tracking (E-Tracking) technology evaluation of alcohol on endothelial function, To explore the role of alcohol in endothelial dysfunction. ET technology using real-time, non-invasive, simple and reproducible evaluation of the advantages of a non-drinker of vascular endothelial function, can be done early and accurate assessment, Conducive to improving people's sense of self-care, drinking norms reasonable to impose an embargo on the people of the harm of alcohol in order to more effectively prevent vascular disease, in order to reduce and control of cardiovascular and cerebrovascular disease morbidity and mortality provide important clinical basis.Select a different degree of alcohol history of 127 cases of persons, age 35-50 years old, both male subjects have been examined to exclude high blood pressure, high cholesterol, diabetes and serious heart, liver, kidney, thyroid and other diseases, In accordance with different length of alcohol and alcohol consumption were observed in groups. Select non-drinking habits of men 75 cases of healthy normal control group. Application of E-tracking technology to track real-time polygraph subjects bilateral common carotid artery wall movement, Calculated analysis of internal systolic diameter (Ds), internal diastolic diameter (Dd), stiffness parameter (β), elasticity modulus (Eρ), arterial compliance (AC), augmentation index (AI), one-point pulse wave velocity calculated fromβvalue (PWVβ), and parameters derived from the observation group compared with the normal statistical analysis of carotid artery to assess endothelial function.The research findings show: (1) Different alcohol groups compared with normal control group:With the increase in alcohol consumption, stiffness parameter (β), elasticity modulus (Eρ), augmentation index (AI), one-point pulse wave velocity calculated fromβvalue (PWVβ) values gradually increased, arterial compliance (AC) decreased; A small number of group and control group values in each parameter between groups showed no significant difference (P>0.05), there is no statistical significance. the middle groups, a large number of groups and control groups to compare, the statistical test with significant difference (P<0.05). A small number of groups, the middle groups, a large number of groups compared among the three groups with significant difference (P<0.05). (2) Different age group and drinking normal control group: With the increase in the age of wine,AlcoholⅠgroup and the control group to compare the value of the parameters measured no significant difference (P>0.05), there is no statistical significance. AlcoholⅡgroup, alcoholⅢgroup, alcoholⅣgroup and control groups to compare, the statistical test with significant difference (P<0.05). AlcoholⅠgroup, alcoholⅡgroup, alcoholⅢgroup, alcoholⅣgroup compared among the four groups with significant difference (P<0.05). (3) Left and right carotid artery parameters showed no significant difference (P>0.05), there is no statistical significance.The results show that: With the number of years of alcohol consumption and alcohol increase inβ, Eρ, A I, PWVβof common carotid artery as drinking alcohol and increasing age was significantly higher, AC with the number of years of alcohol consumption and alcohol increase in a significant reduction. ET technology indicators in each parameterβ, Ep, AC, AI, PWVβassociated with a certain degree of ethanol, prompted the crowd to drink in varying degrees of atherosclerosis and vascular endothelial damage to the extent of the seriousness of the closely related, description of ethanol (alcohol) is the impact of vascular endothelial function in a risk factor. Vascular echo tracking technology to the early, accurate assessment of the alcohol to varying degrees of vascular endothelial function, in the clinical application of a wide range of values,can be used as vascular endothelial function testing method of choice.