Effects Of Rosuvastatin On Plasma Inflammation Factor Levels In Patients With Acute Coronary Syndrome

Objective To study effects of rosuvastatin on plasma intefleukin-18(IL-18) and C-creactive protein(CRP) levels in patients with acute coronary syndrome and to investigate the effects of rosuvastatin on decreasing blood lipid level.Methods All patients with coronary heart disease were divided into two groups, including 30 cases of unstable angina group,20 cases of stable angina group,there were 20 cases in normal control group,levels of IL-18,CRP were detected.Unstable angina group was given rosuvastatin(10mg a day) every night for 6 weeks.Levels of TG,TC,HDL,LDL,IL- 18,CRP were measured before and after treatment.Results The serum levels of IL-18 and CRP were distinctively different in the three groups(F=190.961,P＜0.01;F:22.359,P＜0.01).The serum levels of IL-18 and CRP on patients with coronary heart disease were much higher than nomal control',those in unstable angina group higher than in angina group.Levels of IL-18,CRP in unstable angina group were distinctively lower after treatment(t=12.553,P＜0.01;t=7.991, P＜0.01),and so as TC,LDL,and level of HDL advanced.Conclusion IL-18 and CRP are the indexes for inflammation of atherosclerosis,it plays an important role in plaque stability.Rosuvastatin can decrease levels of serum TC,LDL,IL-18,CRP in patients with acute coronary syndrome and hoist HDL,reduce inflammation,stable plaque.