The Correlation Between Benign Prostatic Hyperplasia And Erectile Dysfunction And The Risk Factors Under Different Treatments

Partâ… The correlation between benign prostatic hyperplasia and erectile dysfunctionObjections:To study the correlation among lower urinary tract symptoms(LUTS),benign prostatic hyperplasia(BPH) and erectile dysfunction(ED).Methods:86 male patients who were diagnosed as BPH in our hospital during January 2006 to February 2008 were collected.According to age, they were allocated into three groups:≤65(n=20),65-75(n=42) and≥75(n=24).All patients' medical record were collected,including age,prostate volume,residual urine,International Prostate Symptom Score(IPSS),International Index of Erectile Function(IIEF-5) etc. Statistic methods were used to analyze the 86 patients' data.Results:The morbidity rate of ED was 68.60%for all 86 patients, and were 55.00%66.67%and 83.33%for each group of age≤65,65-75 and≥75 respectively,and were 47.37%,68.18%,86.96%for mild LUTS, moderate LUTS and severe LUTS respectively.The morbidity rate of ED was related to the age and the degree of LUTS.There was mild correlation between IPSS and prostate volume(r = 0.37,P＜0.001),high correlation between IPSS and residual urine(r = 0.818,P＜0.001),mild correlation between prostate volume and residual urine(r = 0.369,P＜0.001).There was moderate negative correlation between age and IIEF-5(r =-0.688, P＜0.001),mild negative correlation between residual urine and IIEF-5 (r=-0.596,P＜0.001),moderate negative correlation between IPSS and IIEF-5(r =-0.686,P＜0.001),no correlation between prostate volume and IIEF-5(r =-0.205,P＞0.05).After correcting for age,there was also correlation between IPSS and IIEF-5(r =-0.428,P＜0.001).Conclusions:There was mild correlation between IPSS and prostate volume.There was high correlation between IPSS and residual urine,so residual urine can be used as an important parameter to evaluate the degree of LUTS.There was moderate negative correlation among age,IPSS and ED, so age and LUTS were the impact factors to ED.LUTS was the independent risk factor to ED.Partâ…¡The risk factors of erectile dysfunction for the aged patients with BPH under different treatmentsObjections:To identify the risk factors of erectile dysfunction(ED) for the aged patients with benign prostatic hyperplasia(BPH) under different treatment.Methods:128 male patients who were diagnosed as BPH in our hospital during January 2006 to October 2007 were collected.All patients' medical record were collected,including age,prostate volume,residual urine, International Prostate Symptom Score(IPSS),International Index of Erectile Function(IIEF-5) etc.According to the treatment,they were allocated into two groups:transurethral resection of prostate(TURP) (n=62) and medication(n=66).The IIEF-5 assessment was repeated at a 6-month follow-up.Statistic methods were used to analyze the 86 patients' data.Results:The morbidity rate of ED was 68.60%for all 128 patients. Age(P＜0.05),residual urine(P＜0.05),diabetes(P＜0.05),coronary heart disease(P＜0.05),hypertension(P＜0.005),smoking(P＜0.025), severity of LUTS(P＜0.025) were the most important impact factors for ED before any treatments.Six months after TURP,the rate of patients reporting ED increased 12.90%.All the patients whose prostate volume was larger than 60ml before operation and who were observed intraoperative capsular perforation were reported ED after TURP.The rate of retrograde ejaculation was 90.91%.The rate of ED increased 14.70%for patients who used Finasteride,and decreased 12.50%for patients who usedα₁-AR antagonists only.Conclusions:The incidence of newly reported ED after TURP was 12.90 %.Risk factors for its occurrence were prostate volume and intraoperative capsular perforation.The rate of retrograde ejaculation was 90.91%.Finasteride was associated with a negative effect on sexual functioning.In contrast,α₁-AR antagonists had no negative effect on sexual functioning,soα₁-AR antagonists can be considered as the first-line medicine for the treatment of LUTS/BPH with the demand of sexual function.