An Experimental Study On The Preventive Effects Of Cordyceps Sinensis (Berk) Sacc On Pulmonary Fibrosis

ObjectivesTo explore the preventive effects of Cordyceps sinensis(Berk) Sacc(CS) on pulmonary fibrosis.Materials and MethodsIntra-trachea injection of bleomycin(BLM) was performed to induce animal model of pulmonary fibrosis.From 7d before the injection to 14d after the injection, the suspension of CS powder(CSP) or equal solvent was administrated everyday. Then,loaded swimming stamina assessment,blood gas analysis,and histological examination were performed for the diagnosis of pulmonary fibrosis.ResultsIntra-trachea injection of BLM could result in significant changes in experimental rats,such as increase of the lung index(lung weight/body weight), decrease of the swimming time and the PO₂ of the arterial blood,and seriously pathological fibrotic changes in lung structure.Compared with BLM-solvent group, the BLM-induced pulmonary fibrotic changes were significantly attenuated in the BLM-CSP group.ConclusionCordyceps sinensis(Berk) Sacc can prevent and attenuate the pulmonary fibrosis.