Analysis Of Irrational Use Of Antibiotics In Clinic

Aim: To investigate the use of antibiotics and the reasonable application in a basic level hospital, and analyze what cause the irrational use of antibiotics, in order to provide the basis for clinical reasonable application, reducing waste and developing clinical pharmacy servings.Methods: We investigated the total income amount of medical treatment, medicine and antibiotics in a basic level hospital in year of 2006, respectively, and calculated the percentage of medicine income to total income amount of medical treatment and the percentage of income of antibiotics to medicine income. Sort the first 20 kinds of antibiotics in terms of consumption. Sampled 720 shares of medical records of the hospital in 2006 at random, then indagated and analyzed the use of antibiotics for in-patients(including drug kinds, using frequency and ways, combination with other drugs) and the preventive application of antibiotics to surgical patients (including drug kinds, using frequency and ways, combination with other drugs. besides the using occasion and time). Indagated and analyzed the bacteria checkout and sensitivity in 2007; and evaluated the rationality of antibiotics application to surgery and nonsurgery patients.Result: The income percentage of antibiotics to all drugs in the hospital was 32.06%. Antibiotics were used excessively, of which 62 kinds of 16 categories were used commonly in medical records, and preventively administered to 92.39% surgery patients; the rate of combination is 73.08%. The rate of antibiotics used in nonsurgery inpatients was 55.26%; the rate of combination was 49.83%. Sensitivity and pathogenic examines were do for 21.80% patients. The rate of antibiotics application to all the inpatients was 65.42%. The rate of combination was 58.81%. Antibiotics were abused during perioperative period. Irrational application to surgery inpatients was more seriously than to nonsurgery inpatients. The samples from all the inpatients in 2007 were 3981 shares, from which 1857 plants were separated, including 1020 plants of gram-negative bacterium, 163 plants of gram-positive bacterium and 674 plants of epiphyte.Conclusion: The sale proportion of antibiotics in the hospital was on the high side. Cephalosporins were too widely used in this hospital. The rate of application and combination of antibiotics to nonsurgery inpatient was also on the high side, while the examination of sensitivity and pathogeny was so low. Consequently, the rate of preventive applications to surgery patients was a little high. So the unreasonable uses of antibiotics are excessive in this hospital. It is expected to enhance the level of reasonable use of antibiotics.