Ultrasonic Study On Kidney Hyperfil Tration Of Type Ⅱ Diabetes Mellitus

Objective:This study was designed to evaluate the kidney in the healthy population and newly diagnosed Type II diabetic patients using 2-D and color Doppler ultrasonic , and to analyze the hemodynamic and morphological characteristics of kidney under the different conditions, investigate the ultrasonic changes of the Diabetic patients' kidney in the state of ultrafiltration , with a view to the early diagnosis of Diabetic Nephropathiy and provide a reliable reference to help guide clinical treatment and prognosis.Methods:Randomly selected 300 healthy cases whose age between 20～69-year-old as normal control group, in which 20 to 29 years old, 30 to 39 years old, 40 to 49 years old, 50 to 59 years old, 60 to 69 years old , each of the age group with 60 cases. At the same time, 60 newly diagnosed Type II diabetes cases were selected between 40 to 49-year-old as diabetes group.First, these 360 subjects were examined with ultrosound , measuring the size of the kidney and blood flow parameters, standardizing the data.Second,they were measured of glomerular filtration rate (GFR), using cystatin C in normal control group, and radionuclide scan in diabetes group and normal control group with the same age.Third, divided the diabetes group (120 kidneys) into normal GFR group and unusual GFR group based on the GFR values , compared ultrasound measurement datas with the normal control groupwith the same age.T test were used to compare of the sample rate between two groups ,and analysis ofvariance to that between vary groups, x~2 test to that of constitutes rate,multi-variable analysis to parameters association analysis. Statistical analysis wasdone using SPSS10.0 software, the differences was statically significant when it isP<0.05.Results:Normal kidney size is in the range of 41～82 ml/m2, increasing as the age grows.Diabetes kidney are larger than the healthy, especially in high-filtration state,significantly to the increase in the thickness of the kidney ,as to say kidneyenlargement.The increase of the kidney size and blood flow were the mainperformance in the high-filtration kidneys,yet the the flow velocity andresistance index changes was not obvious.The size of the kidney and renal blood flowwas positively correlated with GFR..Conclusions:Early sonographic examination of diabetic patients with measuring of the kidneyvolume and renal blood flow can lead us to find kidney ultrafiltration in time, andpredict kidney damage in diabetes mellitus.