Relationship Between Metabolic Syndrome And Incident Type 2 Diabetes Mellitus

Objective To analyze the relationship of metabolic syndrome(MS)and its components at baseline to the follow-up incidence of diabetes mellitus.Methods Study objects sources of the cohort data in Jiangsu province from the project of Multiple Metabolic Disorders and Metabolic Syndrome. A total of 3598 people with complete analysis of information was include. The National Cholesterol Education Program Adult Treatment Panel III Asian (ATPâ…¢)criterion was used to define MS. In present study, we compared the T2DM risk among individuals with or without MS at baseline. Also the interaction between the IFG and other components of MS were evaluated. Results (1)128 patients with DM were discovered during the fo1low-up survey with all incidence of 6.4%,the incidence being 5.8% in males and 6.8% in females.(2)The proportions of those with different MS components except the HDL-C were higher among the T2DM patients than those without T2DM. The proportion of baseline high fasting glucose was 64.06% among those who were diagnosed as with T2DM during the follow-up survey.Of the MS components high fasting glucose had the highest proportion among the T2DM patients.(3)The relative risk of those with different MS components was higher than those without MS components. Adjusted for age and sex,the results showed that fasting glucose contributed mostly to T2DM with a relative risk (aRR) of 5.93(4.11-8.56).(4) with the increase of the MS components, the risk of incident T2DM increased, and the aRR of individuals combined five MS components was 13.03 (4.88~34.80) . (5) Compared with those without both MS and high fasting glucose.the relative risk of T2DM for persons with MS but without high fasting glucose was 1.38 (0.68-2.80) times that for those without MS and with normal fasting glucose.(6) the result of interaction between the IFG and other components of MS was SI = 1.41 but without significance. Conclusion MS was an independent indicator for incidence of T2DM.Among the MS components, high fasting glucose contributes mostly toT2DM;the relative risk of T2DM for persons with MS but without high fasting glucose was 1.38. Those without high fasting glucose but with MS should take early intervention measures to prevent the incidence of T2DM.