Synergism And Attenuation Effects Of Taurine On Tumor Bearing Mice Treated With Chemotherapy

Objective:To investigate synergism and attenuation effects of taurine(Tau) on tumor bearing mice treated with chemotherapy.Methods:S₁₈₀ and Lewis lung carcinoma bearing mice were given different doses of Tau combined with cyclophosphamide(CTX) via two administration routes(intravenous injection and intragastric administration).The tumor inhibition rate,the spleen index and the thymus index were observed.The count of bone marrow nucleate cells,the count and classification of white blood cells and the phagocytic activity of neutrophilic granulocyte and monocyte were measured.The lymphocyte proliferation and the phagocytic activity of peritoneal macrophage were analyzed.Results:The tumor inhibition rates of Tau combined with CTX on S₁₈₀ and Lewis lung carcinoma bearing mice were higher than CTX used alone.Tau could enhance the tumor-inhibiting effect of CTX.Compared with the CTX group,the count of bone marrow nucleate cells,the count of white blood cells especially the neutrophilic granulocytes and the phagocytic activity of neutrophilic granulocyte and monocyte increased significantly when Tau was used together with CTX,which demonstrated that Tau could improve myelosuppression of CTX on tumor bearing mice.Tau could attenuate the toxicity of CTX on the immune organ of tumor bearing mice,protect the spleen and thymus and promote the growth of the two organs.Compared with the CTX group,Tau used together with CTX could enhance the lymphocyte proliferation and increase the phagocytic activity of peritoneal macrophage,which indicated that Tau could improve the toxic effect of CTX on immune system.Conclusion:Tau has synergism and attenuation effects on tumor bearing mice treated with chemotherapy.The present study provided experimental data for exploiting Tau as a neotype ancillary drug of chemotherapy.